One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: 1745-07-9, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 1745-07-9, Name is 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline, molecular formula is C11H15NO2
Synthesis and pharmacological evaluation of verapamil analogs with restricted molecular flexibility
Several analogs of verapamil, which are characterized by a reduced molecular flexibility, have been synthesized.Their pharmacological activity has been evaluated on guinea-pig atria (negative chronotropic and inotropic activities) and guinea-pig aorta strips (vasorelaxing actvity).Their ability to displace the calcium antagonist (-)-desmethoxyverapamil ((-)-<3H>-D888)-on kitten cardiac tissue has also been evaluated.The pharmacological results are in accord with the previously reported models for negative inotropic and chronotropic activities of verapamil-likecompounds, but fail to give information about the conformation(s) that act on smooth muscle. verapamil / calcium antagonists / chronotropic activity/ inotropic activity / reduced flexibility
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Recommanded Product: 1745-07-9, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 1745-07-9, in my other articles.
Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem