In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 1612-65-3, name is 2-Methyl-1,2,3,4-tetrahydroisoquinoline, introducing its new discovery. HPLC of Formula: C10H13N
Synthesis of some N-methyl-1,2,3,4-tetrahydroisoquinolines by Friedel-Crafts cyclisation using benzotriazole auxiliary
1-Hydroxymethylbenzotriazole reacts with phenylethylamines to give the respective N,N-bis(benzotriazol-1-ylmethyl)phenylethylamines, which are then subject to an intramolecular Friedel-Crafts cyclisation at room temperature to yield N-benzotriazol-1-ylmethyl-1,2,3,4-tetrahydroisoquinolines. These crystalline UV- and oxygen-stable products can be reduced at room temperature to the corresponding N-methyl-1,2,3,4-tetrahydroisoquinoIines using NaBH4. The method offers an elegant approach to a wide range of N-methylated 1,2,3,4-tetrahydroisoquinolines since it can be applied not only for the synthesis of 1,2,3,4-tetrahydroisoquinolines with electron-donating substituents on the aromatic moiety, but also for deactivated derivatives. All steps involved work under very mild conditions in high to excellent yields.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 1612-65-3, and how the biochemistry of the body works.HPLC of Formula: C10H13N
Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem