Electric Literature of 166591-85-1, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 166591-85-1, 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid, introducing its new discovery.
Organic photoredox catalytic decarboxylative cross-coupling of: Gem -difluoroalkenes with unactivated carboxylic acids
The monofluoroalkene substructure plays a crucial role in various fields of organic synthesis, pharmacology and materials science. However, a redox-neutral direct monofluoroalkenylation of prevalent alkyl sources still remains very challenging. Herein, the first monofluoroalkenylation of naturally abundant unactivated carboxylic acids via organic photoredox catalytic decarboxylation has been developed. This redox-neutral approach avoids the utilization of presynthesized redox-active esters and high energy irradiation, providing a mild and efficient strategy for direct decarboxylative cross-coupling reactions of unactivated carboxylic acids. Furthermore, it allows the remarkable and challenging late-stage monofluoroalkenylation of complex molecular architectures such as bioactive ramipril, gemfibrozil, dehydroabietic acid, enoxolone and saccharide-derived cyclic alpha-oxy acid.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 166591-85-1. In my other articles, you can also check out more blogs about 166591-85-1
Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem