Reference of 1745-07-9, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 1745-07-9, 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline, introducing its new discovery.
INDOLE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS
The present invention relates to dopamine D4 ligands having the general formula I wherein (a) one of Y1 and Y2 is N, which is bound to Y4, and the other of Y1 and Y2 is CO, CS, SO, or SO2 and Y4 is CH2 ; (b) one of Y1 and Y2 is N, which is bound to Y4, and the other of Y1 and Y2 is CH2 and Y4 is CO, CS, SO or SO2; or (c) one of Y 1 and Y2 is N, which is bound to Y4, and the other of Y1 and Y2 is CH2 and Y4 is CH 2; Y3is Z–CH2, CH2–Z or CH 2CH2, and Z is O or S; provided that when Y1 is N, Y3 may not be Z–CH2; W is a bond or an O, S, CO, CS, SO or SO2 group; n is 0-5, m is 0-5 and m+n is 1-10; provided that when W is O or S, then n?2 and m?1; when W is CO, CS, SO or SO2, then n?1 and m?1; X is C, CH or N; provided that when X is C, the dotted line indicates a bond, and when X is N or CH, the dotted line is absent; R1-R9 are independently selected from hydrogen, halogen, cyano, nitro, amino, hydroxy, C1-6-alkyl-amino, di-C1-6-alkyl-amino, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C1-6 alkoxy, C1-6-alkylthio, C1-6-alkyl substituted with hydroxy or thiol, C3-8-cycloalkyl, C3-8-cycloalkyl-C 1-6-alkyl, acyl, thioacyl, aryl, trifluoromethyl, trifluoromethylsulfonyl, and C1-6 alkylsulfonyl; R10 is hydrogen, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C1-6-alkyl substituted with hydroxy or thiol, C3-8-cycloalkyl, C3-8-cycloalkyl-C1-6-alkyl, aryl, aryl-C1-6-alkyl, acyl, thioacyl, C1-6-alkylsulfonyl, trifluoromethylsulfonyl or arylsulfonyl, or a pharmaceutically acceptable acid addition salt thereof. The compounds of the invention are potent dopamine D4 receptor ligands.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 1745-07-9. In my other articles, you can also check out more blogs about 1745-07-9
Reference：
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem