77497-95-1, Name is (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid hydrochloride, belongs to tetrahydroisoquinoline compound, is a common compound. Quality Control of (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid hydrochlorideIn an article, once mentioned the new application about 77497-95-1.
A series of novel 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives were designed, synthesized and assayed for their activities against aminopeptidase N (APN/CD13) and MMP-2. The results showed that most compounds exhibited higher inhibitory activities against APN than that of MMP-2. Within this series, compound 12h (IC50 = 6.28 ¡À 0.11 muM) showed similar inhibitory activities compared with Bestatin (IC50 = 5.55 ¡À 0.01 muM), and it could be used as novel lead compound for the future APN inhibitors development as anticancer agents.
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Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem