New Advances in Chemical Research in 2021. In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 1745-07-9, name is 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline, introducing its new discovery. Product Details of 1745-07-9
We have designed and synthesized a series of indole-based sigma2 receptor ligands containing 5,6-dimethoxyisoindoline or 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline as pharmacophore. In vitro competition binding assays showed that all ten ligands possessed low nanomolar affinity (Ki = 1.79?5.23 nM) for sigma2 receptors and high subtype selectivity (Ki (sigma2)/Ki (sigma1) = 56?708). Moreover, they showed high selectivity for sigma2 receptor over the vesicular acetylcholine transporter (>1000-fold). The corresponding radiotracers [18F]16 and [18F]21 were prepared by an efficient one-pot, two-step reaction sequence with a home-made automated synthesis module, with 10?15% radiochemical yield and radiochemical purity of >99%. Both radiotracers showed high brain uptake and sigma2 receptor binding specificity in mice.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Product Details of 1745-07-9, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 1745-07-9, in my other articles.
Reference：
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem