Chemical Research Letters, May 2021. Research speed reading in 2021. name: (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid hydrochloride, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 77497-95-1, Name is (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid hydrochloride, molecular formula is C10H12ClNO2. In a Article，once mentioned of 77497-95-1
A series of novel 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives were designed, synthesized and assayed for their activities against aminopeptidase N (APN/CD13) and MMP-2. The results showed that most compounds exhibited higher inhibitory activities against APN than that of MMP-2. Within this series, compound 12h (IC50 = 6.28 ± 0.11 muM) showed similar inhibitory activities compared with Bestatin (IC50 = 5.55 ± 0.01 muM), and it could be used as novel lead compound for the future APN inhibitors development as anticancer agents.
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Reference：
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem