The important role of 1-Phenyl-1,2,3,4-tetrahydroisoquinoline

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 22990-19-8. In my other articles, you can also check out more blogs about 22990-19-8

Research speed reading in 2021. An article , which mentions Reference of 22990-19-8, molecular formula is C15H15N. The compound – 1-Phenyl-1,2,3,4-tetrahydroisoquinoline played an important role in people’s production and life., Reference of 22990-19-8

Reported is an achiral CpxRhIII/chiral carboxylic acid catalyzed asymmetric C?H alkylation of diarylmethanamines with a diazomalonate, followed by cyclization and decarboxylation to afford 1,4-dihydroisoquinolin-3(2H)-one. Secondary alkylamines as well as nonprotected primary alkylamines underwent the transformation with high enantioselectivities (up to 98.5:1.5 e.r.) by using a newly developed chiral carboxylic acid as the sole source of chirality to achieve enantioselective C?H cleavage by a concerted metalation-deprotonation mechanism.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 22990-19-8. In my other articles, you can also check out more blogs about 22990-19-8

Reference：
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem