New discoveries in chemical research and development in 2021. In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Reference of 1612-65-3, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 1612-65-3, name is 2-Methyl-1,2,3,4-tetrahydroisoquinoline. In an article，Which mentioned a new discovery about 1612-65-3
The hydrochlorides of molecular segments of apomorphine [2 (3′,4′ dihydroxybenzyl) 1,2,3,4 tetrahydroisoquinoline, 2 (3′,4′ dihydroxybenzyl) piperidine, and 1,2,3,4 tetrahydroisoquinoline with their respective N methyl and N n propyl homologs] and N,N dialkylated dopamine compounds were synthesized and studied for LD50 in intact mice; stereotypy in intact mice; curving of the body in unilaterally caudectomized mice; rotation in 6 hydroxydopamine lesioned rats, and activation of adenylate cyclase in homogenates of mouse caudate nuclei. Instead of dopaminergic effects 1 (3′,4′ dihydroxybenzyl) 2 methyl 1,2,3,4, tetrahydroisoquinoline and 2 methyl 1,2,3,4, tetrahydroisoquinoline showed cholinergic ones. These effects were blocked in atropine pretreated animals. Of the N,N dialkylated dopamine compounds synthesized, the N n propyl N n butyldopamine ranked in all tests as the strongest dopamine receptor agonist and N methyl N n propyldopamine as the weakest. In contrast, N,N dimethyldopamine and 1 (3,4 dihydroxyphenylethyl) piperidine showed no dopaminergic effects. The effectiveness of the dopaminergic agonists depended on the length of the N alkyl substituents suggesting interactions with hydrophobic regions of the receptor site.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 1612-65-3. In my other articles, you can also check out more blogs about 1612-65-3
Reference：
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem