Research speed reading in 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. An article , which mentions Synthetic Route of 1612-65-3, molecular formula is C10H13N. The compound – 2-Methyl-1,2,3,4-tetrahydroisoquinoline played an important role in people’s production and life., Synthetic Route of 1612-65-3
The hydrogen bond acceptor strength of 40 tertiary amines has been measured by Fourier transform – infrared (FTIR) spectrometry from their 1:1 complexation constant towards 4-fluorophenol in CCl4 at 25C (the pKHB scale). Also measured was the frequency shift, Deltanu(OH), of the nu(OH) band of methanol hydrogen-bonded to these amines. The comparison of the thermodynamic hydrogen bond basicity scale, pKHB, with the spectroscopic one, Deltanu(OH), and with the Bronsted pKa scale, points to the great sensitivity of pKHB to steric effects. The pKHB scale of tertiary amines extends from 2.71 for quinuclidine to -0.34 for N,N-diisopropyl-3-pentylamine. The main factors governing this important variation (17 kJ·mol-1 on the Gibbs energy scale) are the electron-withdrawing inductive effect and various kinds of steric effects (e.g., opening of the CNC angles and hindrance to OH fixation on the nitrogen lone pair). Infrared (IR) spectra show the attachment of 4-fluorophenol to the nitrile nitrogen of Me2NCH2C?N and Me2NCH2CH2C?N, to the oxygen of N-methylmorpholine, and to the pi electrons of (HC?CCH2)3N and (PhCH2)3N, in addition to the attachment to the amino nitrogen. In (PhCH2)3N, the electron-withdrawing effect of the three benzyl substituents and, mainly, the very important congestion of the nitrogen lone pair reduce the nitrogen hydrogen-bond basicity almost to nothing, so that tribenzylamine, a nitrogen Bronsted base, turns to a pi base in hydrogen bonding. From this example, the large differences between the pKHB and pKa scales of organic bases are emphasized.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 1612-65-3. In my other articles, you can also check out more blogs about 1612-65-3
Reference：
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem