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Chemical Research Letters, May 2021. Research speed reading in 2021. Recommanded Product: 57196-62-0, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 57196-62-0, Name is 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, molecular formula is C10H14ClNO. In a Article,once mentioned of 57196-62-0

The structural transformations of compound 1 {[Co(44pba)2] 4·(DMF)3·(EtOH) 0.25·(H2O)4}n [44pba = 4-(4-pyridyl) benzoate] were followed during the exchange of DMF and ethanol molecules by methanol at room temperature. The new phases obtained 2 {[Co(44pba)2]·(MeOH)2.5·(H 2O)}n, 3 {[Co(44pba)2(MeOH)2] 2·(MeOH)2.5·(H2O) 2}n and 4 {[Co(44pba)2(MeOH) 2]·(MeOH)0.5·(H2O) 0.5}n were studied using differential scanning calorimetry, thermogravimetric analysis and X-ray diffraction methods. The final phase 4 reverts back to 1 upon soaking 4 in a dry DMF-ethanol mixture as evidenced by the powder diffraction data and infrared spectra.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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A series of 4-(3,4-dihydro-1H-isoquinolin-2yl)-pyridines and analogous quinolines was prepared and evaluated as NR1/2B subtype selective NMDA receptor antagonists. 2-Hydroxyalkylamino substitution combines high affinity with selectivity (vs alpha1 and M1 receptors) and activity in vivo.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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New research progress on 1745-07-9 in 2021. Related Products of 1745-07-9, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 1745-07-9, molcular formula is C11H15NO2, introducing its new discovery.

Amides and ketones were intramolecularly coupled in the presence of KOt-Bu/DMF. The reaction provided good yields of a variety of isoquinolinones. A reaction mechanism of radical addition and subsequent E2-elimination is proposed.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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Chemical Research Letters, May 2021. Electric Literature of 22990-19-8, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.22990-19-8, Name is 1-Phenyl-1,2,3,4-tetrahydroisoquinoline, molecular formula is C15H15N. In a Article,once mentioned of 22990-19-8

A simple synthesis of three dihydroisoquinolines and five 1-substituted tetrahydroisoquinolines from the parent compound involves N-chlorination/dehydrochlorination with KO2 and subsequent organometallation.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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New Advances in Chemical Research in 2021. Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis, and research on the structure and performance of functional materials.In a patent, 57196-62-0, name is 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, introducing its new discovery. Electric Literature of 57196-62-0

A Cp?Rh-based nonanuclear triangular macrocycle complex [(Cp?Rh)9L3(NO3)4.5(MeOH)](OTf)4.5 (1), a Cp?Ir-based trinuclear complex [(Cp?Ir)3L(MeCN)4](OTf)3 (2) and a linear heptanuclear heterometallic complex [(Cp?Ir)6ZnL2(MeCN)8(MeOH)2](OTf)8 (3) (Cp? = eta5-pentamethylcyclopentadienyl) have been synthesized from a 2-(4-(pyridin-4-yl)phenyl)-1H-imidazole-4,5-dicarboxylic acid proligand. These complexes were further characterized by X-ray crystallography, 1H NMR, DOSY NMR, IR spectroscopy, and elemental analyses.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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Chemical Research Letters, May 2021. name: 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.57196-62-0, Name is 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, molecular formula is C10H14ClNO. In a Article,once mentioned of 57196-62-0

C61H52Ag2N2O6P2, orthorhombic, P212121 (no. 19), a = 14.4634(11) A, b = 17.7866(18) A, c = 20.5509(19) A, V = 5286.8(8) A3, Z = 4, Rgt(F) = 0.0424, wRref(F2) = 0.0997, T = 298(2) K.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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Chemical Research Letters, May 2021. category: tetrahydroisoquinoline, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1745-07-9, Name is 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline, molecular formula is C11H15NO2. In a Article,once mentioned of 1745-07-9

Capsazepine as well as its derivatives and analogues are general inhibitors of constriction of human small airways. From a systematic variation of the capsazepine structure, divided into four regions, SARs were established. This paper concerns the chlorination of the A-ring as well as the replacement of the catechol with bioisosteric groups. It is revealed that chlorination of the A-ring has a profound effect on activity. Moreover, di-chlorination of the 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline structure results in a 10-fold increase in potency compared to capsazepine.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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Research speed reading in 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. An article , which mentions Synthetic Route of 17680-55-6, molecular formula is C9H10BrN. The compound – 7-Bromo-1,2,3,4-tetrahydroisoquinoline played an important role in people’s production and life., Synthetic Route of 17680-55-6

The present invention provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by EBNA1 activity, such as, but not limited to, cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and/or rheumatoid arthritis. The present invention further provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection and/or lytic EBV infection.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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Diuretic and saluretic tetrahydro-isoquinoline derivatives of the Formula (I) STR1 wherein R stands for hydrogen or chlorine, R1 and R2 are hydrogen, methoxy or ethoxy, and R3 and R4 are hydrogen or methyl, and a process for the preparation thereof as well as pharmaceutical compositions containing as active ingredients isoquinoline derivatives of the Formula (I). The compounds of Formula I are prepared by reacting a 2-amino-tetrahydro-isoquinoline derivative of the Formula (II) STR2 with a carboxylic acid derivative of the Formula (III) STR3 wherein x stands for chlorine, –OH, –OCH2 CN, –OCH3, –OC2 H5, –OCOOCH3 or –OCOOC2 H5 R5 and R6 stand for hydrogen or together from CHN(CH3)2 and in case of the Formula (Ia) STR4 splitting off the protective group in alkaline medium.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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Chemical Research Letters, May 2021. Research speed reading in 2021. Application of 1745-07-9, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 1745-07-9, Name is 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline, molecular formula is C11H15NO2. In a Article,once mentioned of 1745-07-9

A series of new benzimidazole-thiazolidinedione hybrids has been synthesized and evaluated for their cytotoxic potential against a selected human cancer cell lines of prostate (PC-3 and DU-145), breast (MDA-MB-231), lung (A549) and a normal breast epithelial cells (MCF10A). Among the tested compounds, 11p exhibited promising cytotoxicity with IC50value of 11.46 ± 1.46 muM on A549 lung cancer cell line and did not show significant toxicity on normal MCF10A cells. Lung cancer cells (A549) have been used to know the mechanism of cell growth inhibition and apoptosis inducing effect with compound 11p. The treatment of A549 cells with 11p showed typical apoptotic morphology like cell shrinkage, chromatin condensation and horseshoe shaped nuclei formation. Flow-cytometry analysis revealed the G2/M phase of cell cycle arrest in a dose dependent manner. Preliminary mechanistic studies suggested that the cell migration was inhibited through the disruption of F-actin protein. Acridine orange-ethidium bromide (AO-EB), DAPI, annexin V-FITC/propidium iodide, rhodamine-123 and MitoSOX assays suggested the induction of apoptosis in A549 cells by compound 11p.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem