The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ) is researched.Application In Synthesis of cis-Dichlorobis(pyridine)platinum(II).Farrell, Nicholas; Ha, Tam T. B.; Souchard, Jean Pierre; Wimmer, Franz L.; Cros, Suzy; Johnson, Neil P. published the article 《Cytostatic trans-platinum(II) complexes》 about this compound( cas:15227-42-6 ) in Journal of Medicinal Chemistry. Keywords: platinum pyridine complex antitumor isomerism. Let’s learn more about this compound (cas:15227-42-6).
The unusual cytostatic properties of trans-Pt(II) complexes of pyridine, trans-[PtCl2L2] (L = pyridine, 4-methylpyridine), are reported. The complexes demonstrate increased cytostatic activity to L1210 leukemia cells over the cis-pyridine analogs and had activity equivalent to that of cisplatin. The results have implications for the design of structurally novel Pt antitumor agents.
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Reference:
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