So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Norden, Bengt researched the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ).Reference of cis-Dichlorobis(pyridine)platinum(II).They published the article 《Rearrangement of a platinum(II) complex in DNA from intercalation outer-sphere position to non-intercalation coordination》 about this compound( cas:15227-42-6 ) in FEBS Letters. Keywords: DNA interaction platinum dipyridine complex. We’ll tell you more about this compound (cas:15227-42-6).
The interaction of I with DNA was studied using linear dichroism and absorption spectra of DNA solutions containing different concentrations of I. The initial complex had a stability constant of 3 × 105M-1 and the orientation of the I plane was angular, indicating that binding was by intercalation. This intercalated complex slowly transformed into a more stable complex with the orientation of the I plane parallel to the helix axis. In this complex there was coordination of I to N atoms of DNA bases. This complex involved the inner sphere of DNA. When II interacted with DNA, a complex was formed in which inner sphere coordination was present; II did not intercalate with DNA.
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Reference:
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