SDS of cas: 693-67-4. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-Bromoundecane, is researched, Molecular C11H23Br, CAS is 693-67-4, about Efficient Polysulfide-Based Nanotheranostics for Triple-Negative Breast Cancer: Ratiometric Photoacoustics Monitored Tumor Microenvironment-Initiated H2S Therapy. Author is Li, Jie; Li, Xiang; Yuan, Yan; Wang, Qi; Xie, Lisi; Dai, Yunlu; Wang, Wenjun; Li, Lin; Lu, Xiaomei; Fan, Quli; Huang, Wei.
The incidence of triple-neg. breast cancer (TNBC) is difficult to predict, and TNBC has a high mortality rate among women worldwide. A theranostics approach is developed for TNBC with ratiometric photoacoustic monitored thiol-initiated hydrogen sulfide (H2S) therapy. The ratiometric photoacoustic (PA) probe (CY) with a thiol-initiated H2S donor (PSD) to form a nanosystem (CY-PSD nanoparticles) is integrated. In this theranostics approach, H2S generated from PSD is sensed by CY based on ratiometric PA signals, which simultaneously pinpoints the tumor region. Addnl., H2S is cytotoxic toward TNBC cells (MDA-MB 231), showing a tumor inhibition rate of 63%. To further verify its pharmacol. mechanism, proteomics anal. was performed on tumors treated with CY-PSD nanoparticles. Cells are killed by the significant mitochondrial dysfunction via suppressed energy supply and apoptosis initiation. Besides, the observed inhibition of oxidative stress also generates the cytotoxicity. Significant Kyoto Encyclopedia of Genes Genomes pathways related to TNBC are inhibited. This H2S theranostics approach updates the current anticancer therapies which brings promise for women suffering malignant breast cancer.
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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem