Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Amidation of aldehydes using mono-cationic half-sandwich rhodium(III) complexes with functionalized phenylhydrazone ligands.SDS of cas: 1452-77-3.
A series of mono-cationic half-sandwich rhodium(III) complexes have been synthesized in methanol using phenylhydrazone-derived ligands (L1-L6) and the starting precursor [(η5-C5Me5)2Rh2(μ-Cl)2Cl2] in a 2:1 molar ratio. The N,N’-phenylhydrazone complexes have been isolated as tetraphenylborate salts. All complexes were characterized by elemental anal., FT-IR, UV-visible, NMR spectroscopy and mass spectrometry. The mol. structure of complex [(η5-C5Me5)Rh(L1)Cl](BPh4) (1) was confirmed by single-crystal X-ray structure anal. Complex [(η5-C5Me5)Rh(L3)Cl](BPh4) (3) was used as an efficient catalyst for the amide formation reaction, with up to 99% conversion after 2 h in toluene at 110 °C in the presence of hydroxyl amine hydrochloride and sodium bicarbonate.
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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem