So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Fan, Xiao-Nan; Deng, Wei; Liu, Zhen-Jiang; Yao, Zi-Jian researched the compound: Picolinamide( cas:1452-77-3 ).Formula: C6H6N2O.They published the article 《Half-Sandwich Iridium Complexes for the One-Pot Synthesis of Amides: Preparation, Structure, and Diverse Catalytic Activity》 about this compound( cas:1452-77-3 ) in Inorganic Chemistry. Keywords: iridium half sandwich Schiff base complex preparation hydration catalyst; nitrile hydration oxime rearrangement preparation aromatic amide iridium catalyst; crystal structure iridium half sandwich Schiff base complex; mol structure iridium half sandwich Schiff base complex. We’ll tell you more about this compound (cas:1452-77-3).
Several types of air-stable N,O-coordinate half-sandwich iridium complexes containing Schiff base ligands with the general formula [Cp*IrClL] were synthesized in good yields. These stable iridium complexes displayed a good catalytic efficiency in amide synthesis. A variety of amides with different substituents were obtained in a one-pot procedure with excellent yields and high selectivities through the amidation of aldehydes with NH2OH·HCl and nitrile hydration under the catalysis of complexes 1-4. The excellent and diverse catalytic activity, mild conditions, broad substance scope, and environmentally friendly solvent make this system potentially applicable in industrial production Half-sandwich iridium complexes 1-4 were characterized by NMR, elemental anal., and IR techniques. Mol. structures of complexes 2 and 3 were confirmed by single-crystal X-ray anal. Half-sandwich iridium complexes were synthesized, which exhibited a high catalytic activity for amide synthesis in a one-pot procedure with excellent yields and high selectivity through aldehyde amidation or nitrile hydration. The broad substrate scope, mild reaction conditions, and high yields of the products made this catalytic system attractive in the industrial process.
Compound(1452-77-3)Formula: C6H6N2O received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(Picolinamide), if you are interested, you can check out my other related articles.
Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem