Month: March 2022

HPLC of Formula: 693-67-4. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-Bromoundecane, is researched, Molecular C11H23Br, CAS is 693-67-4, about Direct Trifluoromethoxylation without OCF3-Carrier through In Situ Generation of Fluorophosgene. Author is Saiter, Jeremy; Guerin, Thomas; Donnard, Morgan; Panossian, Armen; Hanquet, Gilles; Leroux, Frederic R..

The method represented the preparation of a range of trifluoromethoxylated structures R-OCF3 [R = undecanyl, (CH2)2Ph, 4-BrC6H4CH2, etc.] with no use of an intermediate trifluoromethoxylating reagent, but in situ construction and use of the F3CO anion as a salt, avoiding the presence of a useless side-product resulting from activation of an OCF3 carrier.

Here is just a brief introduction to this compound(693-67-4)HPLC of Formula: 693-67-4, more information about the compound(1-Bromoundecane) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Synthesis and evaluation of 4-(2-fluoro-4-[11C]methoxyphenyl)-5-((2-methylpyridin-4-yl)methoxy)picolinamide for PET imaging of the metabotropic glutamate receptor 2 in the rat brain.Formula: C6H6N2O.

Metabotropic glutamate receptor 2 (mGluR2) has been suggested as a therapeutic target for treating schizophrenia-like symptoms arising from increased glutamate transmission in the human forebrain. However, no reliable positron emission tomog. (PET) radiotracer allowing for in vivo visualization of mGluR2 in the human brain is currently available. In this study, we synthesized 4-(2-fluoro-4-[11C]methoxyphenyl)-5-((2-methylpyridin-4-yl)methoxy)picolinamide ([11C]1) and evaluated its potential as a PET tracer for imaging mGluR2 in the rodent brain. Compound 1, a neg. allosteric modulator (NAM) of mGluR2, showed high in vitro binding affinity (IC50: 26 nM) for mGluR2 overexpressed in human cells. [11C]1 was synthesized by O-[11C]methylation of the phenol precursor 2 with [11C]methyl iodide. After the reaction, HPLC purification and formulation, [11C]1 of 7.4 ± 2.8 GBq (n = 8) was obtained from [11C]carbon dioxide of 22.5 ± 4.8 GBq (n = 8) with >99% radiochem. purity and 70 ± 32 GBq/μmol (n = 8) molar activity at the end of synthesis. In vitro autoradiog. for rat brains showed that [11C]1 binding was heterogeneously distributed in the cerebral cortex, striatum, hippocampus, and cerebellum. This pattern is consistent with the regional distribution pattern of mGluR2 in the rodent brain. The radioactivity was significantly reduced by self- or MNI-137 (a mGluR2 NAM) blocking. Small-animal PET studies indicated a low in vivo specific binding of [11C]1 in the rat brain. The brain uptake was increased in a P-glycoprotein and breast cancer resistant protein double knockout mouse, when compared to a wild-type mouse. While [11C]1 presented limited potential as an in vivo PET tracer for mGluR2, we suggested that it can be used as a lead compound for developing new radiotracers with improved in vivo brain properties.

Here is just a brief introduction to this compound(1452-77-3)Formula: C6H6N2O, more information about the compound(Picolinamide) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Related Products of 1452-77-3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Characterization of pyridine biodegradation by two Enterobacter sp. strains immobilized on Solidago canadensis L. stem derived biochar. Author is Nie, Zimeng; Yan, Binghua; Xu, Yunhai; Awasthi, Mukesh Kumar; Yang, Haijun.

In this study, two pyridine-degrading strains namely Enterobacter cloacae complex sp. BD17 and Enterobacter sp. BD19 were isolated from the aerobic tank of a pesticide wastewater treatment plant. The mixed bacteria H4 composed of BD17 and BD19 at a ratio of 1:1 was immobilized by Solidago canadensis L. stem biochar with a dosage of 2 g·L–1. The highest pyridine removal rate of 91.70% was achieved by the immobilized H4 at an initial pyridine concentration of 200 mg·L-1, pH of 7.0, temperature of 28°C and salinity of 3.0% within 36 h. The main intermediates of pyridine degradation by BD17 were pyridine-2-carboxamide, 2-aminopropanediamide, and 2-aminoacetamide, while 2-picolinic acid, iso-Pr acetate, iso-Pr alc., and acetaldehyde were identified with BD19 by adopting GC-MS technique. Interestingly, there was a possibility of totally mineralization of pyridine and the corresponding degradation pathways of BD17 and BD19 were revealed for the first time.

Here is just a brief introduction to this compound(1452-77-3)Related Products of 1452-77-3, more information about the compound(Picolinamide) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

SDS of cas: 15227-42-6. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Reactivity of neutral platinum(II) complexes. Author is Panasyuk, V. D.; Malashok, N. F..

Kinetic data were obtained for the hydrolysis of [PtenCl2], cis- and trans-[Pt(NH3)2Cl2], cis-[Ptpy2Cl2], and [Pten(NO2)Cl] and for the replacement of Cl by NH3 in trans-[Pt(NH3)2Cl2]. The medium was H2O and mixtures of H2O with MeOH, EtOH, or Me2CO, the concentration of the organic component being 30 and 40 weight % in the hydrolysis and replacement reactions, resp. The lowering of the reaction rate in the presence of the organic component is explained by a structure-dependent contribution of the component to the solvation energy of an intermediate complex. The hydrolysis reaction is assumed to proceed in 2 steps: (1) formation of an intermediate complex by a slow coordination of the H2O mol. to the Pt2+ central ion without release of Cl- and (2) by a quick release of Cl-. The bond polarization occurs during the 1st step and the rate constant, k, should equal the ratio of the activity coefficients of the initial and activated complexes.

Here is just a brief introduction to this compound(15227-42-6)SDS of cas: 15227-42-6, more information about the compound(cis-Dichlorobis(pyridine)platinum(II)) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole( cas:882562-40-5 ) is researched.Safety of 3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole.Diab, Sarah; Yu, Mingfeng; Wang, Shudong published the article 《CDK7 Inhibitors in Cancer Therapy: The Sweet Smell of Success?》 about this compound( cas:882562-40-5 ) in Journal of Medicinal Chemistry. Keywords: review pharmacophore CT7001 SY1365 antitumor CDK7 cancer. Let’s learn more about this compound (cas:882562-40-5).

A review. Cyclin-dependent kinase (CDK) 7 has a unique functional repertoire by virtue of its dual role in transcription and cell cycle progression. Whereas CDK7 is ubiquitously expressed in various types of cancer, its downregulation leads to reduced cell proliferation. Importantly, it is now agreed that targeting transcription selectively limits the synthesis of mRNAs involved in tumor growth without causing an outage of transcription of housekeeping genes. Thus, CDK7 has been considered as a viable therapeutic target in cancer. Indeed, the development of CDK7 inhibitors has gained huge momentum with two mols., CT7001 and SY-1365, currently under clin. development. Herein, we discuss the latest understanding of the role of CDK7 in cancer cells and provide an overview of the pharmacophores of CDK7 inhibitors, their efficacy in various cancer models, and their clin. development.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 15227-42-6, is researched, SMILESS is [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2, Molecular C10H10Cl2N2PtJournal, Journal of Luminescence called Luminescence properties of some platinum(II) complexes. Counter-ion and molecular geometry effects, Author is Diomedi Camassei, F.; Ancarani-Rossiello, L.; Castelli, F., the main research direction is reflection platinum complex structure; luminescence platinum complex structure; phosphorescence platinum complex structure; counter ion platinum complex.Electric Literature of C10H10Cl2N2Pt.

Reflectance and luminescence spectra, and emission lifetimes of 14 charged and neutral Pt(II) crystalline complexes are reported. The lifetimes (in the range of some tens of μsec) indicate that the emissions are due to a spin-forbidden process. On the basis of spectral correlations, the phosphorescence is tentatively identified as due to the lowest d-d ligand field transition when the bonding of the ligand is essentially σ in character, and to a π* → d charge-transfer transition for those complexes in which the ligands themselves have π orbital systems. Both the radiative (kr) and nonradiative (kn) rate constants are sensitive to changes in mol. geometry (cis,trans isomers) and counter-ions. By assuming unitary efficiency for the intersystem crossing to the emitting state, the counter-ion appears to predominantly affect kn through vibrational coupling of the chromophore with the lattice. For the cis forms, both kr and kn are affected in a complex manner, with metal-metal interactions playing an important role. For the trans forms, however, the constancy of the quantum yield with respect to temperature suggests that kn is negligible in comparison to kr, and therefore the trans chromophores behave as isolated systems within the crystalline lattice.

Here is just a brief introduction to this compound(15227-42-6)Electric Literature of C10H10Cl2N2Pt, more information about the compound(cis-Dichlorobis(pyridine)platinum(II)) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Ionic liquid crystals: Synthesis and characterization via NMR, DSC, POM, X-ray diffraction and ionic conductivity of asymmetric viologen bistriflimide salts, published in 2021-04-15, which mentions a compound: 693-67-4, Name is 1-Bromoundecane, Molecular C11H23Br, Computed Properties of C11H23Br.

A series of asym. viologen bistriflimide salts I (R = n-pentyl, dodecyl, octadecyl, etc.) of both short and long alkyl chains were synthesized by the metathesis reaction of lithium triflimide salt with the resp. asym. viologen dibromide salts II in methanol. Their thermotropic liquid crystalline properties were determined by differential scanning calorimetry, polarizing optical microscopy and variable temperature X-ray diffraction techniques. These salts melt into highly-ordered smectic T phases i.e., crystal-to SmT transitions (Tms) at relatively low temperatures (lowest Tm at -12°C) and maintain liquid crystallinity in a wide range of temperatures (8-132°C), with excellent thermal stabilities up to 320°C as determined by thermogravimetric anal. These results differ with respect to the sym. viologen bistriflimide salts I. Ionic conductivity of these salts was also measured by dielec. impedance spectroscopy and found to be in the 10-2.5 S cm-1 range, highlighting their potential as electrolytes at room temperature

Here is just a brief introduction to this compound(693-67-4)Computed Properties of C11H23Br, more information about the compound(1-Bromoundecane) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1-Bromoundecane, is researched, Molecular C11H23Br, CAS is 693-67-4, about Direct Trifluoromethoxylation without OCF3-Carrier through In Situ Generation of Fluorophosgene, the main research direction is trifluoromethoxy compound preparation; fluorophosgene aryl halide trifluoromethoxylation.Recommanded Product: 693-67-4.

The method represented the preparation of a range of trifluoromethoxylated structures R-OCF3 [R = undecanyl, (CH2)2Ph, 4-BrC6H4CH2, etc.] with no use of an intermediate trifluoromethoxylating reagent, but in situ construction and use of the F3CO anion as a salt, avoiding the presence of a useless side-product resulting from activation of an OCF3 carrier.

Here is just a brief introduction to this compound(693-67-4)Recommanded Product: 693-67-4, more information about the compound(1-Bromoundecane) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Far infrared spectra of palladium compounds. II. Pyridine and 2,2′-bipyridyl complexes of palladium(II) and platinum(II), the main research direction is PALLADIUM COMPLEX IR SPECTRA; IR SPECTRA PD COMPLEX; PLATINUM COMPLEX; PYRIDINE COMPLEX; BIPYRIDYL COMPLEX.Computed Properties of C10H10Cl2N2Pt.

The IR spectra of several sq. planar cis and trans Pd(II) and Pt(II) pyridine complexes of the type M(py)2X2 (where X = Cl, Br, and I) have been recorded from 2000 to 50 cm.-1 Comparison of the spectra of complexed pyridine to that of the free base shows 9 normal vibrations have shifted to higher frequencies on the order of 15 to 80 wave numbers The shifts are attributed to changes in the electron d. over the pyridine ring. Only insignificant shifts in a few of the normal modes of the complexed pyridine were observed between the corresponding cis and trans isomers. The assignment of the M-X stretching and bending vibrations as well as possible assignments for the M-N stretching vibrations are given and discussed. The IR spectra of Pd(II)-2,2-bipyridyl (bipy) complexes of the type Pd(bipy)2X2 (where X = Cl, Br, and I) were also recorded from 2000 to 50 cm.-1 Comparison of the spectra to those of the pyridine complexes and the free bipyridine is made. 18 references.

Here is just a brief introduction to this compound(15227-42-6)Computed Properties of C10H10Cl2N2Pt, more information about the compound(cis-Dichlorobis(pyridine)platinum(II)) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Application In Synthesis of cis-Dichlorobis(pyridine)platinum(II). Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Experimental criteria for the applicability of the group model to stretching vibrations of the dichloroplatinum fragment in square planar complexes. Author is Konovalov, L. V.; Pogareva, V. G.; Stanevich, A. E.; Fomina, T. N..

A correlation was found between the Pt-Cl bond length difference, Δr, and the distance, Δν, between the doublet components of the stretching vibration νClPt in cis[PtCl2LL’] complexes with 2 different ligands, L and L’. For Δr = 0-0.025 Å, a constant splitting Δν = 15-25 cm-1 was observed, but for Δr >0.03 Å Δν increased linearly with increasing Δr. The difference was explained in terms of sym. and asym. Pt-Cl bonds.

Here is just a brief introduction to this compound(15227-42-6)Application In Synthesis of cis-Dichlorobis(pyridine)platinum(II), more information about the compound(cis-Dichlorobis(pyridine)platinum(II)) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem