So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Inuki, Shinsuke; Hirata, Natsumi; Kashiwabara, Emi; Kishi, Junichiro; Aiba, Toshihiko; Teratani, Toshiaki; Nakamura, Wataru; Kojima, Yoshimi; Maruyama, Toru; Kanai, Takanori; Fujimoto, Yukari researched the compound: 1-Bromoundecane( cas:693-67-4 ).Recommanded Product: 1-Bromoundecane.They published the article 《Polar functional group-containing glycolipid CD1d ligands modulate cytokine-biasing responses and prevent experimental colitis》 about this compound( cas:693-67-4 ) in Scientific Reports. Keywords: SAR glycolipid ligand polar functional group cytokine biasing colitis. We’ll tell you more about this compound (cas:693-67-4).
The MHC class I-like mol. CD1d is a nonpolymorphic antigen-presenting glycoprotein, and its ligands include glycolipids, such as α-GalCer. The complexes between CD1d and ligands activate natural killer T cells by T cell receptor recognition, leading to the secretion of various cytokines (IFN-γ, IL-4, IL-17A, etc.). Herein, we report structure-activity relationship studies of α-GalCer derivatives containing various functional groups in their lipid acyl chains. Several derivatives have been identified as potent CD1d ligands displaying higher cytokine induction levels and/or unique cytokine polarization. The studies also indicated that flexibility of the lipid moiety can affect the binding affinity, the total cytokine production level and/or cytokine biasing. Based on our immunol. evaluation and investigation of physicochem. properties, we chose bisamide- and Bz amide-containing derivatives 2 and 3, and evaluated their in vivo efficacy in a DSS-induced model of ulcerative colitis. The derivative 3 that exhibits Th2- and Th17-biasing responses, demonstrated significant protective effects against intestinal inflammation in the DSS-induced model, after a single i.p. injection.
If you want to learn more about this compound(1-Bromoundecane)Recommanded Product: 1-Bromoundecane, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(693-67-4).
Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem