Related Products of 693-67-4. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-Bromoundecane, is researched, Molecular C11H23Br, CAS is 693-67-4, about Single-step synthesis and in vitro anti-mycobacterial activity of novel nitrofurantoin analogues. Author is Zuma, Nonkululeko H.; Smit, Frans J.; Seldon, Ronnett; Aucamp, Janine; Jordaan, Audrey; Warner, Digby F.; N’Da, David D..
To improve TB efficacy of nitrofurantoin (NFT), a series of NFT analogs I [R = Me, Et, Bn, etc.] was synthesized and evaluated in vitro for anti-mycobacterial activity against the laboratory strain, Mtb H37Rv and for potential cytotoxicity using human embryonic kidney (HEK-293) and Chinese hamster ovarian (CHO) cells. The NFT analogs showed good safety profiles, enhanced anti-mycobacterial potency, improved lipophilicity, as well as reduced protein binding affinity. Analog I [R = n-Bu] which contains an eight carbon aliphatic chain was the most active, equipotent to isoniazid (INH), a major front-line agent, with MIC90 = 0.5μM, 30-fold more potency than the parent drug, nitrofurantoin (MIC90 = 15μM), and 100-fold more selective towards mycobacteria. Therefore, compound I [R = n-Bu] was identified as a validated hit for further investigation in the urgent search for new, safe and affordable TB drugs.
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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem