Safety of cis-Dichlorobis(pyridine)platinum(II). The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Rotation and conformation of purine ligands in cis-bis(6-oxopurine)platinum compounds. Author is Marcelis, A. T. M.; Van der Veer, J. L.; Zwetsloot, J. C. M.; Reedijk, J..
cis-[PtL2L12]2+ (L = guanosine, 9-methylhypoxanthine, L1 = Me-substituted 1,3-propanediamines, py, α-picoline, 2,2′-bipyridine, 1,2-bis(pyridin-2-yl)ethane) were prepared and studied by NMR. Rotation of L about their Pt-N7 bonds is fast on the NMR time scale, when no Me groups are present on the nitrogens of the 1,3-propanediamine ligands. Rotation is slow when 2 Me groups are present on 1 N of a 1,3-propanediamine chelate. A single Me group on a N hardly seems to interfere with this rotation. Coordinated pyridines do not hinder rotation. In compounds containing 2-methylpyridine ligands, the rotation of the pyridines is slow at room temperature, but becomes fast at higher temperatures Rotation of L, however, is fast on the NMR time scale from -30 to +90°. In compounds containing 1,2-bis(pyridin-2-yl)ethane, rotation of L is slow at low temperatures, but becomes fast at room temperature Furthermore, the results obtained with these compounds show that the purines are preferentially oriented in a head-to-tail arrangement.
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