The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Manipulating Cocrystal Size and Morphology using a Combination of Temperature Cycling and Additives, the main research direction is cocrystal size morphol manipulation temperature cycling additive combination.Related Products of 1452-77-3.
A cooling crystallization of HOBz and isonicotinamide in EtOH yields the 1:1 cocrystal with an extreme needle-like morphol. with an initial mean aspect ratio of ~10 and a size of ~64μm. The use of suspension temperature cycling in combination with tailor-made additives alleviates such extreme needle-like morphols. and increases the average particle size of this cocrystal material. Temperature cycling of the cocrystal suspensions in EtOH alone reduces the mean aspect ratio from 10 to 3.3 while it increases the average crystal size from 64 to 450μm. The further addition of low concentrations of benzamide or nicotinamide suppresses the growth rate at the tip of the needle even more, resulting in a more favorable equant morphol. An iterative mechanism in which additives are incorporated in the lattice structure and released during the temperature increase in each cycle is proposed. Thus, the incorporation of an additive at the normally fast growing and potential needle tips and its release during the temperature increase part of the cycle effectively makes an additive action catalytic. The simultaneous use of temperature cycling and tailor-made additives offers a new and effective approach for the elimination of unsatisfactory needle-like crystal morphologies and a small crystal size during the production of a pharmaceutical cocrystal material. The simultaneous use of temperature cycling and tailor-made additives offers a new and effective approach for morphol. control of a pharmaceutical cocrystal.
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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem