The effect of reaction temperature change on equilibrium 15227-42-6

From this literature《Antitumor platinum compounds. Relation between structure and activity》,we know some information about this compound(15227-42-6)Reference of cis-Dichlorobis(pyridine)platinum(II), but this is not all information, there are many literatures related to this compound(15227-42-6).

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Platinum Metals Review called Antitumor platinum compounds. Relation between structure and activity, Author is Cleare, Michael J.; Hoeschele, J. D., which mentions a compound: 15227-42-6, SMILESS is [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2, Molecular C10H10Cl2N2Pt, Reference of cis-Dichlorobis(pyridine)platinum(II).

A pair of cis leaving groups is necessary but not sufficient for anticancer activity in Pt(II) complexes. The complex should be neutral and the lability of the leaving groups should be about that of Cl in cis-dichlorodiammineplatinum(II) [15663-27-1]. The other ligands should be relatively inert and neutral. Amines are preferred, although varying their structure has not given a clear pattern. However the activity of compounds containing alicyclic amines indicates that some Pt compounds may be highly selective.

From this literature《Antitumor platinum compounds. Relation between structure and activity》,we know some information about this compound(15227-42-6)Reference of cis-Dichlorobis(pyridine)platinum(II), but this is not all information, there are many literatures related to this compound(15227-42-6).

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem