So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Horvath, Gabriela; Premkumar, Thathan; Boztas, Ali; Lee, Eunhye; Jon, Sangyong; Geckeler, Kurt E. researched the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ).Quality Control of cis-Dichlorobis(pyridine)platinum(II).They published the article 《Supramolecular Nanoencapsulation as a Tool: Solubilization of the Anticancer Drug trans-Dichloro(dipyridine)platinum(II) by Complexation with β-Cyclodextrin》 about this compound( cas:15227-42-6 ) in Molecular Pharmaceutics. Keywords: beta cyclodextrin trans dichlorodipyridine platinum complex nanoencapsulation solubilization anticancer. We’ll tell you more about this compound (cas:15227-42-6).
A novel, water-soluble trans-platinum complex was synthesized by inclusion complexation with β-cyclodextrin. The complexation was confirmed by 1H NMR, FT-IR, TGA, and XRD as well as by SEM and EDX. As the precursor complex is not water-soluble, it is difficult to employ it for biol. applications. Here, we report that the encapsulation with cyclodextrin allowed to solubilize the complex to a solubility value of 1.6 mg/mL. Moreover, the cytotoxicity in vitro of the novel inclusion complex indicated a much higher activity after encapsulation.
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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem