The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: cis-Dichlorobis(pyridine)platinum(II)(SMILESS: [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2,cas:15227-42-6) is researched.Related Products of 1452-77-3. The article 《Experimental and theoretical study of the cytotoxic activity of new tetrazole-containing cisplatin analogues and their trans-isomers》 in relation to this compound, is published in Doklady Natsional’noi Akademii Nauk Belarusi. Let’s take a look at the latest research on this compound (cas:15227-42-6).
Quantum chem. calculations within the framework of DFT were carried out for a set of platinum (II) complexes with nitrogen-containing heterocycles. A phys. interpretable QSAR model was developed and a correlation between the biol. activity and structural properties was obtained by means of the multiple linear regression method. The range of new tetrazole-containing platinum (II) complexes was synthesized, and their cytotoxic activity was exptl. determined and compared with the values predicted by the QSAR model. Crucial properties of compounds and their relationship with the mode of action were discussed.
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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem