Gale, Glen R.; Morris, Carl R.; Atkins, Loretta M.; Smith, Alayne B. published the article 《Binding of antitumor platinum compound to cells as influenced by physical factors and pharmacologically active agents》. Keywords: tumor cell platinum compound binding.They researched the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ).Recommanded Product: 15227-42-6. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:15227-42-6) here.
Tritiated cis-dichloro(dipyridine)platinum(II) (I) [15227-42-6] bound to intact Ehrlich ascites tumor cells at 37.deg. in vitro and remained associated with the acid-insoluble fraction of the cells. The extent of binding was also increased with increasing hydrogen ion [1333-74-0] concentration in the medium. The binding was enhanced markedly at 60.deg. and the maximum number of binding sites/cell was .sim.7 billion at this temperature Of 49 chems. and drugs tested, none decreased appreciably the rate and extent of binding, whereas certain heavy metals, and compounds that compromise membrane permeability enhanced the binding. Human and bovine lymphocytes had similar binding characteristics, but bound much more I/unit of cell volume.
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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem