The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Platinum compounds with anti-tumor activity, the main research direction is platinum compound tumor structure; platinum compound antitumor structure.Application of 15227-42-6.
Ten Pt coordination complexes with different ligands, comprising both Pt(II) and Pt(IV) complexes of which the cis-compounds all possessed at least some antitumor activity and the trans-compounds were inactive, were tested as to their effect on cell survival and the induction and repair of DNA damage in cultured Chinese hamster cells (CHO). The Pt-compounds were divided in 3 groups on the basis of their cytotoxicity. The compounds with high cytotoxicity were also active antitumor drugs, but a clear correlation between cytotoxicity and antitumor activity was not observed All compounds inhibited semi-conservative DNA synthesis and induced DNA repair replication. No induction of DNA single strand breaks and DNA cross-links was detected. However, the occurrence of alkali labile sites in the DNA of treated CHO cells demonstrated the induction of unidentified DNA bases damages. The cis-compounds were more mutagenic than the trans-compounds
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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem