So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Ali, Imdad; Manzoor, Hiba; Imran, Muhamad; Shafiulah; Shah, Muhammad Raza researched the compound: 1-Bromoundecane( cas:693-67-4 ).Formula: C11H23Br.They published the article 《Synthesis of nitrogen containing biocompatible non-ionic surfactants and investigation for their self-assembly based nano-scale vesicles》 about this compound( cas:693-67-4 ) in Tenside, Surfactants, Detergents. Keywords: nitrogen simvastatin nonionic surfactant self assembly biocompatibility. We’ll tell you more about this compound (cas:693-67-4).
Nonionic surfactants are increasingly interesting because of the solubility and release of drugs. Here, a synthesis of four nonionic nitrogen-containing surfactants is reported. In the synthesis, sulfonamide was reacted with alkyl halides of different lipophilicity. The synthesized nonionic surfactants were characterized by 1H NMR and mass spectroscopy. Their critical micelle concentration (CMC) was determined with a UV spectrophotometer. The self-assembly of surfactants to form drug-loaded, niosomal vesicles with Simvastatin as model drug was investigated. The resulting niosoaml vesicles were characterized by at. force microscope (AFM), zeta-sizer, and UV spectrophotometer for shape, size, polydispersity index, zeta potential, and drug inclusion efficiency. Their biocompatibility has been determined by blood hemolysis and cell toxicity tests. The synthesized surfactants showed low CMC values and were able to form nano-sized round niosomal vesicles with a homogeneous population and surface negativity. Depending on the lipophilicity, they absorbed an increased amount of drug. The biocompatibility studies show that the surfactants are hemocompatible and non-toxic. The results of the study confirm that the synthesized nonionic surfactants are suitable for the solubilization and release of hydrophobic drugs as efficient novel biocompatible carriers.
In addition to the literature in the link below, there is a lot of literature about this compound(1-Bromoundecane)Formula: C11H23Br, illustrating the importance and wide applicability of this compound(693-67-4).
Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem