So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Jin, Xin; Fu, Hong-Chen; Wang, Mei-Yan; Huang, Shouying; Wang, Yue; He, Liang-Nian; Ma, Xinbin researched the compound: 4-Chloro-4′-ethynyl-1,1′-biphenyl( cas:57399-11-8 ).HPLC of Formula: 57399-11-8.They published the article 《Chemodivergent Synthesis of One-Carbon-Extended Alcohols via Copper-Catalyzed Hydroxymethylation of Alkynes with Formic Acid》 about this compound( cas:57399-11-8 ) in Organic Letters. Keywords: alc preparation regioselective diastereoselective enantioselective chemoslective green chem; alkyne formic acid hydroxymethylation copper catalyst. We’ll tell you more about this compound (cas:57399-11-8).
Here an intriguing strategy for the chemodivergent copper-catalyzed hydroxymethylation of alkynes RCCR1 (R = Ph, cyclopropyl, thiophen-2-yl, etc.; R1 = Ph, H, 3-fluorophenyl, 2-fluorophenyl, etc.) and R2CCH [R2 = 4-(4-methylphenyl)phenyl, 4-(4-fluorophenyl)phenyl, 4-(thiophen-2-yl)phenyl, etc.] and 9-ethynylphenanthrene with formic acid and hydrosilane has been developed. By simply tuning the amount of formic acid and reaction temperature, distinct one-carbon-extended primary alcs., i.e., allylic alcs. (E)/(Z)-RCH=C(R1)CH2OH and β-branched alkyl alcs., (S)-R2CH(CH3)CH2OH and (S)-2-(phenanthren-9-yl)propan-1-ol were produced with high levels of Z/E-, regio-, and enantioselectivity.
This literature about this compound(57399-11-8)HPLC of Formula: 57399-11-8has given us a lot of inspiration, and I hope that the research on this compound(4-Chloro-4′-ethynyl-1,1′-biphenyl) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem