So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Cleare, Michael J.; Hoeschele, J. D. researched the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ).SDS of cas: 15227-42-6.They published the article 《Antitumor platinum compounds. Relation between structure and activity》 about this compound( cas:15227-42-6 ) in Platinum Metals Review. Keywords: platinum complex structure cancer; antitumor platinum complex structure. We’ll tell you more about this compound (cas:15227-42-6).
A pair of cis leaving groups is necessary but not sufficient for anticancer activity in Pt(II) complexes. The complex should be neutral and the lability of the leaving groups should be about that of Cl in cis-dichlorodiammineplatinum(II) [15663-27-1]. The other ligands should be relatively inert and neutral. Amines are preferred, although varying their structure has not given a clear pattern. However the activity of compounds containing alicyclic amines indicates that some Pt compounds may be highly selective.
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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem