Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Validation Study, Journal of Inorganic Biochemistry called The RP-HPLC measurement and QSPR analysis of log Po/w values of several Pt(II) complexes, Author is Platts, James A.; Oldfield, Steven P.; Reif, Maria M.; Palmucci, Alessandra; Gabano, Elisabetta; Osella, Domenico, which mentions a compound: 15227-42-6, SMILESS is [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2, Molecular C10H10Cl2N2Pt, Synthetic Route of C10H10Cl2N2Pt.
The n-octanol/water partition coefficient, log Po/w, for a set of 24 Pt(II)-complexes was estimated by means of reversed-phase high performance liquid chromatog. (RP-HPLC) technique using a C18 (ODS, octadecyl silane) column as a stationary phase and water/methanol mixtures as mobile phases. Based on the known log P o/w of several Pt(II)-complexes, the authors set a method to correlate the partition coefficient of this kind of complexes with the corresponding retention parameters. The best result was obtained from extrapolation to 0% of the organic modifier (MeOH) of the aqueous eluant. A quant. structure-property relationship (QSPR) was constructed using mol. descriptors derived from d. functional theory (DFT) calculations, which was found to correlate and predict these values with good accuracy. The use of DFT calculations is required because group-additive methods fail due to lack of values for appropriate fragments for many Pt(II)-complexes.
This literature about this compound(15227-42-6)Synthetic Route of C10H10Cl2N2Pthas given us a lot of inspiration, and I hope that the research on this compound(cis-Dichlorobis(pyridine)platinum(II)) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem