So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Tomishige, Keiichi; Tamura, Masazumi; Nakagawa, Yoshinao researched the compound: Picolinamide( cas:1452-77-3 ).Safety of Picolinamide.They published the article 《CO2 Conversion with Alcohols and Amines into Carbonates, Ureas, and Carbamates over CeO2 Catalyst in the Presence and Absence of 2-Cyanopyridine》 about this compound( cas:1452-77-3 ) in Chemical Record. Keywords: carbonate urea carbamate catalyst cyanopyridine cerium oxide; Carbamate; Carbon dioxide; Cerium oxide; Organic carbonate; Urea. We’ll tell you more about this compound (cas:1452-77-3).
Recent progress on the CeO2 catalyzed synthesis of organic carbonates, urea, and carbamates from CO2+alcs., CO2+amines, and CO2+alcs.+amines, resp., is reviewed. The reactions of CO2 with alcs. and amines are reversible ones and the degree of the equilibrium limitation of the synthesis reactions is strongly dependent on the properties of alcs. and amines as the substrates. When the equilibrium limitation of the reaction is serious, the equilibrium conversion of the substrate and the yield of the target product is very low, therefore, the shift of the equilibrium reaction to the product side by the removal of H2O is essential in order to get the target product in high yield. One of the effective method of the H2O removal from the related reaction systems is the combination with the hydration of 2-cyanopyridine to 2-picolinamide, which is also catalyzed by CeO2.
This literature about this compound(1452-77-3)Safety of Picolinamidehas given us a lot of inspiration, and I hope that the research on this compound(Picolinamide) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem