The effect of the change of synthetic route on the product 114362-20-8

This literature about this compound(114362-20-8)Category: tetrahydroisoquinolinehas given us a lot of inspiration, and I hope that the research on this compound(4-Amino-2-(tert-butyl)pyrimidine) can be further advanced. Maybe we can get more compounds in a similar way.

Category: tetrahydroisoquinoline. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 4-Amino-2-(tert-butyl)pyrimidine, is researched, Molecular C8H13N3, CAS is 114362-20-8, about σ-Adduct formation between amines and liquid ammonia. Part 47. On the Chichibabin amination of pyrimidine and N-alkylpyrimidinium salts using liquid ammonia/potassium permanganate. Author is Buurman, Dick J.; Van der Plas, Henk C..

4-Aminopyrimidines I (R1 = C1-4 alkyl) and iminodihydropyrimidines II (R2 = Et, CHMe2) were prepared 2-Alkylpyrimidines were treated with KNH2-NH3-KMnO4 to give I. The reaction of 1,2-diethylpyrimidinium fluoroborate with NH3-KMnO4 gave II (R2 = Et).

This literature about this compound(114362-20-8)Category: tetrahydroisoquinolinehas given us a lot of inspiration, and I hope that the research on this compound(4-Amino-2-(tert-butyl)pyrimidine) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem