Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Organic Chemistry called δ-Valerolactamic quaternary amino acid derivatives: Enantiodivergent synthesis and evidence for stereodifferentiated β-turn-inducing properties, Author is Zhang, Xiaofei; Ligny, Romain; Chewchanwuttiwong, Sopa; Hadade, Rawan; Laurent, Mathieu Y.; Martel, Arnaud; Jacquemmoz, Corentin; Lhoste, Jerome; Bricaud, Sullivan; Py, Sandrine; Dujardin, Gilles, which mentions a compound: 61302-99-6, SMILESS is N[C@H](C)C(NC)=O.[H]Cl, Molecular C4H11ClN2O, Name: D-Alanine methylamide hydrochloride.
Enantiopure (R) and (S) cyclic α,α-disubstituted amino acid derivatives displaying a δ-valerolactam side chain were prepared from a common isoxazolidine precursor. The (R)-configured δ-valerolactam (I) was converted into diastereoisomeric pseudopeptides to investigate its ability to induce secondary structures in peptidomimetics. Conformational studies of these pseudopeptides were carried out in the solid state (X-ray diffraction), in solution (NMR analyses), and in silico (computer-aided conformational anal.), which demonstrated that such quaternary amino acids induce β-turn conformations stable enough to be retained in polar media (DMSO). Incorporation of this new type of α,α-disubstituted amino acid into a representative pseudopeptidic sequence by N- then C-elongation and N-debenzylation is also described herein and could serve for the synthesis of various structured peptidomimetics.
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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem