Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, International Journal of Peptide & Protein Research called Peptide models for β-turns. A circular dichroism study, Author is Crisma, M.; Fasman, G. D.; Balaram, H.; Balaram, P., which mentions a compound: 61302-99-6, SMILESS is N[C@H](C)C(NC)=O.[H]Cl, Molecular C4H11ClN2O, Computed Properties of C4H11ClN2O.
The CD spectra of β-turn model peptides PhCH2O2C-Aib-Pro-Aib-Pro-OMe (I, Aib = NHCMe2CO), Piv-Pro-Aib-NHMe (II, Piv = Me3CCO), Piv-Pro-D-Ala-NHMe (III), and Piv-Pro-Val-NHMe (IV) were examined in methanol, hexafluoroisopropanol, and cyclohexane. Type I and Type II β-turns were observed for I and II, resp., in the solid state, while the Pro-D-Ala sequence adopts a Type II β-turn in a related peptide crystal structure. A class C spectrum was observed for I in various solvents, suggesting a variant of a Type I (III) structure. The Type II β-turn is characterized by a CD spectrum having two pos. CD bands at ∼230 nm and ∼202 nm, a feature observed in III in cyclohexane and methanol and for II in methanol. II exhibits solvent-dependent CD spectra, which may be rationalized by considering Type II, III and V reverse turn structures. IV adopts non-β-turn structures in polar solvents, but exhibits a class B spectrum in cyclohexane suggesting a population of Type I β-turns.
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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem