Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1452-77-3, is researched, SMILESS is O=C(N)C1=NC=CC=C1, Molecular C6H6N2OJournal, Article, Research Support, Non-U.S. Gov’t, Journal of Inorganic Biochemistry called Characterization of copper(II) specific pyridine containing ligands: Potential metallophores for Alzheimer’s disease therapy, Author is Jakusch, Tamas; Hassoon, Azza A.; Kiss, Tamas, the main research direction is copper zinc pyridinylmethylpicolinamide pyridinylmethylpyridinylmethylamino complex formation ESR; Amyloid β; Copper; Electron Paramagnetic Resonance spectroscopy; Metallophore; Reactive oxygen species; Speciation.Recommanded Product: Picolinamide.
Two amide group containing pyridine derivatives, N-(pyridin-2-ylmethyl)picolinamide (PMPA) and N-(pyridin-2-ylmethyl)-2-((pyridin-2-ylmethyl)amino)acetamide (DPMGA), have been investigated as potential metallo-phores in the therapy of Alzheimer’s disease. Their complex formation with Cu(II) and Zn(II) were characterized in details. Unexpectedly not only the Cu(II) but also the Zn(II) was able to induce deprotonation of the amide-NH, however, it occurred only at higher pH or at higher metal ion concentrations than the biol. conditions. At μM concentration level mono complexes (MLH-1) dominate with both ligands. Direct fluorescence and reactive oxygen species (ROS) producing measurements prove that both ligands are able to remove Cu(II) from its amyloid-β complexes (CuAβ). Correlation was also established between the conditional stability constant of the Cu(II) complexes with different ligands and their ability of inhibition of ROS production by CuAβ.
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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem