The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Picolinamide( cas:1452-77-3 ) is researched.Product Details of 1452-77-3.Guo, Beibei; de Vries, Johannes G.; Otten, Edwin published the article 《Hydration of nitriles using a metal-ligand cooperative ruthenium pincer catalyst》 about this compound( cas:1452-77-3 ) in Chemical Science. Keywords: nitrile water ruthenium pincer catalyst hydration; amide preparation. Let’s learn more about this compound (cas:1452-77-3).
The catalytic nitrile hydration using ruthenium catalysts based on a pincer scaffold with a dearomatized pyridine backbone. These complexes catalyzed the nucleophilic addition of H2O to a wide variety of aliphatic and (hetero)aromatic nitriles in tBuOH as solvent. Reactions occurred under mild conditions (room temperature) in the absence of additives. A mechanism for nitrile hydration was proposed that is initiated by metal-ligand cooperative binding of the nitrile.
In some applications, this compound(1452-77-3)Product Details of 1452-77-3 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem