The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 4-Chloro-4′-ethynyl-1,1′-biphenyl(SMILESS: C#CC1=CC=C(C2=CC=C(Cl)C=C2)C=C1,cas:57399-11-8) is researched.Recommanded Product: 1452-77-3. The article 《Copper-Catalyzed and Proton-Directed Selective Hydroxymethylation of Alkynes with CO2》 in relation to this compound, is published in Angewandte Chemie, International Edition. Let’s take a look at the latest research on this compound (cas:57399-11-8).
An intriguing strategy for copper-catalyzed hydroxymethylation of alkynes with CO2 and hydrosilane was developed. Switched on/off a proton source, for example, t-BuOH, direct hydroxymethylation and reductive hydroxymethylation could be triggered selectively, delivering a series of allylic alcs. and homobenzylic alcs., resp., with high levels of Z/E, regio- and enantioselectivity. Such a selective synthesis is attributed to the differences in response of vinylcopper intermediate to proton and CO2. The protonation of vinylcopper species is demonstrated to be prior to hydroxymethylation, thus allowing a diversion from direct alkyne hydroxymethylation to reductive hydroxymethylation in the presence of a suitable proton source.
Although many compounds look similar to this compound(57399-11-8)Application In Synthesis of 4-Chloro-4′-ethynyl-1,1′-biphenyl, numerous studies have shown that this compound(SMILES:C#CC1=CC=C(C2=CC=C(Cl)C=C2)C=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem