In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis and Antiplasmodial Activity of New Indolone N-Oxide Derivatives, published in 2010-01-28, which mentions a compound: 57399-11-8, mainly applied to indolone oxide preparation antiplasmodial activity, Reference of 4-Chloro-4′-ethynyl-1,1′-biphenyl.
A series of 66 new indolone-N-oxide derivatives, e.g. I, was synthesized with three different methods. Compounds were evaluated for in vitro activity against CQ-sensitive (3D7), CQ-resistant (FcB1), and CQ and pyrimethamine cross-resistant (K1) strains of Plasmodium falciparum (P.f.), as well as for cytotoxic concentration (CC50) on MCF7 and KB human tumor cell lines. Compound II (5-methoxy-indolone-N-oxide analog) had the most potent antiplasmodial activity in vitro (<3 nM on FcB1 and = 1.7 nM on 3D7) with a very satisfactory selectivity index (CC50 MCF7/IC50 FcB1: 14623; CC50 KB/IC50 3D7: 198823). In in vivo experiments, compound I (dioxymethylene derivatives of the indolone-N-oxide) showed the best antiplasmodial activity against Plasmodium berghei, 62% inhibition of the parasitemia at 30 mg/kg/day. The article 《Synthesis and Antiplasmodial Activity of New Indolone N-Oxide Derivatives》 also mentions many details about this compound(57399-11-8)Reference of 4-Chloro-4′-ethynyl-1,1′-biphenyl, you can pay attention to it or contacet with the author([email protected]) to get more information.
Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem