SDS of cas: 61302-99-6. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: D-Alanine methylamide hydrochloride, is researched, Molecular C4H11ClN2O, CAS is 61302-99-6, about New Amino Acids for the Topographical Control of Peptide Conformation: Synthesis of All the Isomers of α,β-Dimethylphenylalanine and α,β-Dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid of High Optical Purity. Author is Kazmierski, Wieslaw M.; Urbanczyk-Lipkowska, Zofia; Hruby, Victor J..
The synthesis of all four diastereoisomers of α,β-dimethylphenylalanine, H2NCMe(CHMePh)CO2H, (4) as well as those of α,β-dimethyl-1,2,3,4,-tetrahydroisoquinoline-3-carboxylic acid (I and II) have been accomplished in high yield and high optical purity. Mol. mechanics calculations on the Nα-acetyl and N-methylcarboxamide derivatives of (3R,4R)-I and (3R,4S)-II indicate large and moderate energy stabilization for the gauche(-) but not the gauche(+) side-chain conformers of (3R,4S)-II and (3R,4R)-I, resp. By symmetry rules, the same holds for (3S,4R)-II and (3S,4S)-I, resp. Thus, these amino acids are potential building blocks for the topog. design of peptides (W. M. Kazmierski et al., 1991) by providing acylated 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives in which a gauche(-) and not a gauche(+) side-chain conformation is energetically more stable for the L-amino acid. Synthetic details and implications of these new amino acids for peptide and protein design are discussed.
The article 《New Amino Acids for the Topographical Control of Peptide Conformation: Synthesis of All the Isomers of α,β-Dimethylphenylalanine and α,β-Dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid of High Optical Purity》 also mentions many details about this compound(61302-99-6)SDS of cas: 61302-99-6, you can pay attention to it, because details determine success or failure
Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem