The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ) is researched.Safety of cis-Dichlorobis(pyridine)platinum(II).Ghezzi, AnnaRita; Aceto, Maurizio; Cassino, Claudio; Gabano, Elisabetta; Osella, Domenico published the article 《Uptake of antitumor platinum(II) complexes by cancer cells, assayed by inductively coupled plasma mass spectrometry (ICP-MS)》 about this compound( cas:15227-42-6 ) in Journal of Inorganic Biochemistry. Keywords: uptake antitumor platinum complex lipophilicity MCF7 cell. Let’s learn more about this compound (cas:15227-42-6).
A systematic study on intracellular Pt uptake and Pt accumulation ratio in breast cancer MCF-7 cell line has been performed on a number of Pt(II)-complexes, namely cisplatin, carboplatin and oxaliplatin, clin. employed as antitumor drugs, trans- and cis-[Pt(Cl)2(pyridine)2] and cis-[Pt(Cl)2(pyridine)(5-SO3H-isoquinoline)] complexes, previously investigated also as potential telomerase inhibitors. In particular, long incubation times have been chosen in order to understand the fate of the complexes in the cells. For this purpose, sub-acute drug concentrations must be employed and, therefore, a very sensitive method of anal. like as inductively coupled plasma mass spectrometry (ICP-MS) superior to the widely employed at. absorption spectroscopy (AAS) has been adopted. Any relationships among uptake/accumulation and several parameters such as drug structure, lipophilicity, drug concentration and incubation time have been sought and analyzed: the bulk of data point for a passive diffusion mechanism through the cell membrane.
The article 《Uptake of antitumor platinum(II) complexes by cancer cells, assayed by inductively coupled plasma mass spectrometry (ICP-MS)》 also mentions many details about this compound(15227-42-6)Safety of cis-Dichlorobis(pyridine)platinum(II), you can pay attention to it, because details determine success or failure
Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem