Wang, Hai; Wang, Liang; Wang, Sai; Dong, Xue; Zhang, Jian; Xiao, Feng-Shou published the article 《Aerobic Activation of C-H Bond in Amines Over a Nanorod Manganese Oxide Catalyst》. Keywords: aerobic activation amine nanorod manganese oxide catalyst; amide preparation green chem.They researched the compound: Picolinamide( cas:1452-77-3 ).Application of 1452-77-3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1452-77-3) here.
The development of heterogeneous catalysts for the synthesis of pharmaceutically relevant compounds is always important for chem. research. Here, we report a selective aerobic oxidation of aromatic and aliphatic amines to corresponding amides over a nanorod manganese oxide (NR-MnOx) catalyst. The kinetic studies reveal that the NR-MnOx catalyzed amine-to-amide reaction proceeds the oxidative dehydrogenation of the amines into nitriles, followed by hydrolysis of nitrile into amides. The NR-MnOx exhibits fast kinetics and high selectivities in these steps, as well as hinders the byproduct formation. More importantly, the NR-MnOx catalyst is stable and reusable in the continuous recycle tests with water as a sole byproduct, exhibiting superior sustainability and significant advancement to outperform the traditional amide production route in acidic or basic media with toxic byproducts.
Different reactions of this compound(Picolinamide)Application of 1452-77-3 require different conditions, so the reaction conditions are very important.
Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem