Month: April 2022

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Picolinamide(SMILESS: O=C(N)C1=NC=CC=C1,cas:1452-77-3) is researched.HPLC of Formula: 882562-40-5. The article 《Ionic liquid catalysed aerobic oxidative amidation and thioamidation of benzylic amines under neat conditions》 in relation to this compound, is published in Green Chemistry. Let’s take a look at the latest research on this compound (cas:1452-77-3).

Tetrabutylammonium hydroxide (TBAOH) was discovered as a highly efficient and green catalyst for aerobic oxidation of the α-methylene carbon of primary amines as well as benzylic groups RCH2NH2 (R = Ph, pyren-1-yl, thiophene-2-yl, etc.) into the corresponding amides RC(O)NH2 and ketones R1C(O)C6H5 [R1 = Ph, pyridin-2-yl, C6H5C(O)] and 9H-fluoren-9-one under neat conditions. Ionic liquid TBAOH catalyzed aerobic oxidation of benzyl amines to benzamides and with elemental sulfur was described; and the corresponding benzylbenzothioamides RC(S)NHCH2R were obtained under metal-free, oxidant-free and base-free conditions. Applicability at the gram scale for the synthesis of the desired amides/ketones is also demonstrated with the present protocol.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole( cas:882562-40-5 ) is researched.HPLC of Formula: 882562-40-5.Kwiatkowski, Nicholas; Zhang, Tinghu; Rahl, Peter B.; Abraham, Brian J.; Reddy, Jessica; Ficarro, Scott B.; Dastur, Anahita; Amzallag, Arnaud; Ramaswamy, Sridhar; Tesar, Bethany; Jenkins, Catherine E.; Hannett, Nancy M.; McMillin, Douglas; Sanda, Takaomi; Sim, Taebo; Kim, Nam Doo; Look, Thomas; Mitsiades, Constantine S.; Weng, Andrew P.; Brown, Jennifer R.; Benes, Cyril H.; Marto, Jarrod A.; Young, Richard A.; Gray, Nathanael S. published the article 《Targeting transcription regulation in cancer with a covalent CDK7 inhibitor》 about this compound( cas:882562-40-5 ) in Nature (London, United Kingdom). Keywords: THZ1 THZ1R bioTHZ1 preparation transcription regulation antitumor CDK7 inhibitor; phenylaminopyrimidine derivative THZ1 preparation antitumor CDK7 inhibitor transcription. Let’s learn more about this compound (cas:882562-40-5).

Tumor oncogenes include transcription factors that co-opt the general transcriptional machinery to sustain the oncogenic state, but direct pharmacol. inhibition of transcription factors has so far proven difficult. However, the transcriptional machinery contains various enzymic cofactors that can be targeted for the development of new therapeutic candidates, including cyclin-dependent kinases (CDKs). Here the authors present the discovery and characterization of a covalent CDK7 inhibitor, THZ1, which has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7. Cancer cell-line profiling indicates that a subset of cancer cell lines, including human T-cell acute lymphoblastic leukemia (T-ALL), have exceptional sensitivity to THZ1. Genome-wide anal. in Jurkat T-ALL cells shows that THZ1 disproportionally affects transcription of RUNX1 and suggests that sensitivity to THZ1 may be due to vulnerability conferred by the RUNX1 super-enhancer and the key role of RUNX1 in the core transcriptional regulatory circuitry of these tumor cells. Pharmacol. modulation of CDK7 kinase activity may thus provide an approach to identify and treat tumor types that are dependent on transcription for maintenance of the oncogenic state.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Berezin, V. I.; Ganin, V. V.; Kovrikov, A. B.; Lipnitskii, I. V.; Rogalevich, N. L. published the article 《Spectral and structural properties of the crystalline complex dichlorodi(pyridine)palladium》. Keywords: IR Raman palladium pyridine chloride.They researched the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ).COA of Formula: C10H10Cl2N2Pt. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:15227-42-6) here.

An IR and Raman spectroscopic investigation of crystalline PdPy2Cl2 was made. The vibrational frequencies were measured in the region from 3500 to 30 cm-1. The assignments of the observed bands were made on the basis of the frequency calculation for trans- and cis-PdPy2Cl2 plane and nonplanar configurations, using force constants, modelled from constants of [Pd(NH3)4]2+ and [PdCl4]2-. The calculation results were used to specify the metal-ligands stretching constants and their interactions.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Mohammad, Abdulkarim-Talaq; Al-Mohammedi, Mohammad Hameed; Ghdhayeb, Mohammed Zghair; Husain Al-Majidi, Suaad Mohammed published the article 《Coumarin dimers of benzidine and phenylenediamine cores: synthesis, characterisation and mesomorphic properties》. Keywords: coumarin Schiff base liquid crystal preparation diastereoselective mesomorphic property.They researched the compound: 1-Bromoundecane( cas:693-67-4 ).Formula: C11H23Br. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:693-67-4) here.

Three new homologous series of coumarin heterocycles-derived mesogens I (X = biphenyl-4,4′-diyl, benzene-1,4-diyl, 3,3′-dimethoxy-biphenyl-4,4′-diyl; R = C6H13, C10H21, C14H29, etc.) have been synthesized and characterized. The sym. dimers of coumarin contain two Schiff base moieties as connecting groups with Ph or biphenyl central cores. Thermal, mesophase behaviors and textural types were studied by DSC and POM instrumentations. The nematic mesophase was enhanced prominently for most of the compounds, and appeared in relatively medium to long alkyl chain at both terminals of the mols.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Spectra and structure of pyridine coordination compounds》. Authors are Herbelin, F.; Herbelin, J. D.; Mathieu, J. P.; Poulet, H..The article about the compound:cis-Dichlorobis(pyridine)platinum(II)cas:15227-42-6,SMILESS:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2).Quality Control of cis-Dichlorobis(pyridine)platinum(II). Through the article, more information about this compound (cas:15227-42-6) is conveyed.

Ir absorption spectra of 15 coordination compounds of pyridine with Pt, Rh, and Ir have been observed, 100-3200 cm.-1; in some cases uv and Raman spectra have also been observed. The effect of coordination on the vibration spectrum of pyridine, the structure of the coordinated units, and the differences in the spectra of cis-trans isomers are discussed.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Stetsenko, A. I.; Dmitrieva, E. S.; Yakovlev, K. I. published an article about the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6,SMILESS:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2 ).Application of 15227-42-6. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:15227-42-6) through the article.

[Pt2(NH3)4Cl2L]Cl2 (L = adenine, adenosine) were prepared by the addition of ligand to cis-[Pt(NH3)2Cl2] solution [Pt(NH3)2L](NO3)2 were obtained by adding L to cis-[Pt(NH3)2(H2O)2](NO3)2 solution 2-Aminopyrimidine (L1) and 2-amino-4-phenylpyrimidine (L2) reacted with aqueous K2[PtCl4] to yield trans-[PtL12Cl2] and trans-[PtL22Cl2], resp. The cis-[PtA2L12]Cl2 (A = NH3, pyridine, 0.5 ethylenediamine) were obtained by the substitution reaction of cis-[PtA2Cl2] with 2-aminopyrimidine. The cis-[PtA2(H2O)2](NO3)2 reacted with 2-aminopyrimidine to afford cis-[PtA2L12](NO3)2 and cis-[PtA2L1](NO3)2 (A = NH3, 0.5 ethylenediamine), depending on the stoichiometric ratios of the reactants.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Thermal migration of amines in platinum(II) complexes, published in 1978-08-31, which mentions a compound: 15227-42-6, mainly applied to platinum complex amine thermal migration; ammine thermal migration platinum complex; pyridine thermal migration platinum complex; methylamine thermal migration platinum complex; ethylenediamine thermal migration platinum complex; aniline thermal migration platinum complex; quinoline thermal migration platinum complex; picoline thermal migration platinum complex; toluidine thermal migration platinum complex; piperidine thermal migration platinum complex; hydroxyquinoline thermal migration platinum complex, Related Products of 15227-42-6.

Derivatog. data indicate that the 1st stage of the thermal conversion of (LH)2[PtCl4] (L = NH3, MeNH2, piperidine, pyridine, γ-picoline, PhNH2, p-toluidine, 8-hydroxyquinoline, quinoline) or (enH2)[PtCl4] is the cleavage of HCl and the formation of PtL2Cl2. All the complexes studied fall into 2 groups according to the temperature of the beginning of the process: (1) complexes with a temperature for the start of thermal reaction at 180 – 200° contain amines the basicity constants of which are >10-5 and (2) complexes with decomposition temperatures at 130-50° contain amines the basicity constants of which are <10-8. Although many compounds look similar to this compound(15227-42-6)Related Products of 15227-42-6, numerous studies have shown that this compound(SMILES:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, RSC Advances called The antitumor activity of 4,4′-bipyridinium amphiphiles, Author is Wang, Senlin; Wu, Hongshuai; Chen, Fanghui; Zhang, Yu; Zhang, Yuchen; Sun, Baiwang, which mentions a compound: 693-67-4, SMILESS is CCCCCCCCCCCBr, Molecular C11H23Br, Reference of 1-Bromoundecane.

A series of 4,4′-bipyridinium amphiphiles, compounds I [n = 8-16] were synthesized and their anticancer activities were further evaluated. MTT assay showed that the cytotoxicity first increased and then decreased with the growth of carbon chains (8-16 C) at both ends of bipyridyl. Specifically, compounds with saturated carbon chains consisting of 13 carbons at both ends of bipyridyl displayed the best cell inhibitory activity with IC50 values in the low-micromolar range, which were even superior to that of cisplatin, against all the tested human cancer cells and cisplatin-resistant A549 cancer cells in vitro. In addition, compound I [n = 13] could evidently arrest the G2/M phase of the cell cycle in a dose-dependent manner. Moreover, this study demonstrates the potent performance of compound I [n = 13] in cell growth inhibition and apoptosis induction via a conceivable approach of membrane damage.

Although many compounds look similar to this compound(693-67-4)Reference of 1-Bromoundecane, numerous studies have shown that this compound(SMILES:CCCCCCCCCCCBr), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Reference of 1-Bromoundecane. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1-Bromoundecane, is researched, Molecular C11H23Br, CAS is 693-67-4, about Chalcogen bonding and liquid crystallinity: Understanding the anomalous behaviour of the 4′-(alkylthio)[1,1′-biphenyl]-4-carbonitriles (nSCB). Author is Cruickshank, Ewan; Strachan, Grant J.; Storey, John MD; Imrie, Corrie T..

The synthesis and characterization of the first eleven members of the 4′-(alkylthio)[1,1′-biphenyl]-4-carbonitriles, I [n = 1, 2, 3, etc.] was reported. All eleven members I showed monotropic liquid crystal behavior. The first six members were exclusively nematogenic, the seventh member showed nematic and smectic A phases and the higher homologues only smectic A behavior. A comparison of their transitional behavior with that of the corresponding alkyl and alkyloxy-cyanobiphenyls revealed a new pattern of behavior. Specifically, the nematic-isotropic transition temperatures showed a large decrease on passing from the methylthio to ethylthio homologues. This unexpected behavior was interpreted in terms of chalcogen bonding.

Although many compounds look similar to this compound(693-67-4)Reference of 1-Bromoundecane, numerous studies have shown that this compound(SMILES:CCCCCCCCCCCBr), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1452-77-3, is researched, SMILESS is O=C(N)C1=NC=CC=C1, Molecular C6H6N2OJournal, Article, Chemical Science called Hydration of nitriles using a metal-ligand cooperative ruthenium pincer catalyst, Author is Guo, Beibei; de Vries, Johannes G.; Otten, Edwin, the main research direction is nitrile water ruthenium pincer catalyst hydration; amide preparation.COA of Formula: C6H6N2O.

The catalytic nitrile hydration using ruthenium catalysts based on a pincer scaffold with a dearomatized pyridine backbone. These complexes catalyzed the nucleophilic addition of H2O to a wide variety of aliphatic and (hetero)aromatic nitriles in tBuOH as solvent. Reactions occurred under mild conditions (room temperature) in the absence of additives. A mechanism for nitrile hydration was proposed that is initiated by metal-ligand cooperative binding of the nitrile.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem