Month: April 2022

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Santos, Peter J.; Cao, Zhen; Zhang, Jianyuan; Alexander-Katz, Alfredo; Macfarlane, Robert J. researched the compound: 1-Bromoundecane( cas:693-67-4 ).COA of Formula: C11H23Br.They published the article 《Dictating Nanoparticle Assembly via Systems-Level Control of Molecular Multivalency》 about this compound( cas:693-67-4 ) in Journal of the American Chemical Society. Keywords: dictating nanoparticle assembly system multivalency. We’ll tell you more about this compound (cas:693-67-4).

Nanoparticle assembly can be controlled by multivalent binding interactions between surface ligands, indicating that more precise control over these interactions is important to design complex nanoscale architectures. It has been well-established in natural materials that the arrangement of different mol. species in three dimensions can affect the ability of individual supramol. units to coordinate their binding, thereby regulating the strength and specificity of their collective mol. interactions. However, in artificial systems, limited examples exist that quant. demonstrate how changes in nanoscale geometry can be used to rationally modulate the thermodn. of individual mol. binding interactions. As a result, the use of nanoscale design features to regulate mol. bonding remains an underutilized design handle to control nanomaterials synthesis. Here we demonstrate a polymer-coated nanoparticle material where supramol. bonding and nanoscale structure are used in conjunction to dictate the thermodn. of their multivalent interactions, resulting in emergent bundling of supramol. binding groups that would not be expected on the basis of the mol. structures alone. Addnl., we show that these emergent phenomena can controllably alter the superlattice symmetry by using the mesoscale particle arrangement to alter the thermodn. of the supramol. bonding behavior. The ability to rationally program mol. multivalency via a systems-level approach therefore provides a major step forward in the assembly of complex artificial structures, with implications for future designs of both nanoparticle- and supramol.-based materials.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Sun, Kai-Jin; Cai, Zhao-Sheng published the article 《Synthesis, characterization and crystal structure of 2-pyridinecarboxamide》. Keywords: pyridinecarboxamide preparation crystal mol structure.They researched the compound: Picolinamide( cas:1452-77-3 ).SDS of cas: 1452-77-3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1452-77-3) here.

The 2-pyridinecarboxamide was synthesized from 2-picoline through two-steps reaction. Initially, 2-picoline was converted into 2-cyanopyridine by ammoxidation in a stainless-steel fixed-bed reactor at 370°C with V2O5 loaded on TiO2 as catalyst. The 2-cyanopyridine was transformed into 2-pyridinecarboxamide through oxidation hydrolysis in basic solution using MnO2 as oxidant at 70°C. The crystal structure of 2-pyridinecarboxamide was investigated using X-ray diffraction and SHELX 2018/3 (sh) software and the result indicated that 2-pyridinecarboxamide crystallized in the monoclinic system, space group P21/n with a = 5.207(2), b = 7.097(3), c = 16.243(6) Å, V = 595.7 (4) Å3; Z = 4.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Category: tetrahydroisoquinoline. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Mass spectrometry of cis-platin in urine. Author is Sumino, Kimiaki; Mio, Takaya; Yamamoto, Ryoji; Ishigami, Joji; Kamidono, Sadao; Hamami, Gaku.

The mass spectra of cisplatin  [15663-27-1] and its analogs are presented. A urine sample of a cancer patient treated with cisplatin was extracted with 0.1N-HCl and then washed with COMe2/CHCl3. The component containing Pt was eluted with 2N-HBr using an ion exchange chromatog. technique. The mass spectrum of the component showed the change from Cl-type to Br-type as the unchanged type of carrier ligand. Thus, mass spectrometry may be a useful method to elucidate the action mechanism of cisplatin.

Although many compounds look similar to this compound(15227-42-6)Category: tetrahydroisoquinoline, numerous studies have shown that this compound(SMILES:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Synthetic Route of C6H6N2O. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Metabotropic glutamate receptor 5 (mGlu5)-positive allosteric modulators differentially induce or potentiate desensitization of mGlu5 signaling in recombinant cells and neurons. Author is Hellyer, Shane D.; Albold, Sabine; Sengmany, Kathy; Singh, Junaid; Leach, Katie; Gregory, Karen J..

Allosteric modulators of metabotropic glutamate receptor 5 (mGlu5) are a promising therapeutic strategy for a number of neurol. disorders. Multiple mGlu5-pos. allosteric modulator (PAM) chemotypes have been discovered that act as either pure PAMs or as PAM-agonists in recombinant and native cells. While these compounds have been tested in paradigms of receptor activation, their effects on receptor regulatory processes are largely unknown. In this study, acute desensitization of mGlu5 mediated intracellular calcium mobilization by structurally diverse mGlu5 orthosteric and allosteric ligands was assessed in human embryonic kidney 293 cells and primary murine neuronal cultures from both striatum and cortex. We aimed to determine the intrinsic efficacy and modulatory capacity of diverse mGlu5 PAMs [(R)-5-((3-fluorophenyl)ethynyl)-N-(3-hydroxy-3-methylbutan-2-yl)picolinamide (VU0424465), N-cyclobutyl-6-((3-fluorophenyl)ethynyl)picolinamide (VU0360172), 1-(4-(2,4-difluorophenyl)piperazin-1-yl)-2-((4-fluorobenzyl)oxy)ethanone (DPFE), ((4-fluorophenyl) (2-(phenoxymethyl)-6,7-dihydrooxazolo[5,4-c]pyridin-5(4H)-yl)methanone) (VU0409551), 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (CDPPB)] on receptor desensitization and whether cellular context influences receptor regulatory processes. Only VU0424465 and VU0409551 induced desensitization alone in human embryonic kidney 293-mGlu5 cells, while all PAMs enhanced (S)-3,5-dihydroxyphenylglycine (DHPG)-induced desensitization. All mGlu5 PAMs induced receptor desensitization alone and enhanced DHPG-induced desensitization in striatal neurons. VU0424465 and VU0360172 were the only PAMs that induced desensitization alone in cortical neurons. With the exception of (CDPPB), PAMs enhanced DHPG-induced desensitization in cortical neurons. Moreover, differential apparent affinities, efficacies, and cooperativities with DHPG were observed for VU0360172, VU0409551, and VU0424465 when comparing receptor activation and desensitization in a cell type-dependent manner. These data indicate that biased mGlu5 allosteric modulator pharmacol. extends to receptor regulatory processes in a tissue dependent manner, adding yet another layer of complexity to rational mGlu5 drug discovery.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Mattern, I. E.; Cocchiarella, L.; Van Kralingen, C. G.; Lohman, P. H. M. published an article about the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6,SMILESS:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2 ).Application In Synthesis of cis-Dichlorobis(pyridine)platinum(II). Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:15227-42-6) through the article.

Eleven Pt compounds with N donor ligands (aminocyclopentane, aminocyclohexane, pyridine, etc.), previously tested for antitumor activity, were studied for induction of prophage λ and for mutagenicity in the Ames assay, with various strains of Salmonella. The compounds included cis and trans isomers of Pt(II) and Pt(IV) complexes and were tested with and without metabolic activation. All the cis compounds elicited prophage induction, whereas the trans compounds were inactive. Mutagenicity was found only in strains containing the R factor, indicating that SOS-type repair processes are required for the conversion of initial DNA lesions into mutations. Mutation induction was also influenced by the excision-repair process. The 2 trans compounds were not, or only slightly, mutagenic; all other compounds were mutagenic in at least one strain, exhibited a 2-20-fold increase over the spontaneous background level. Addition of liver homogenate had no significant effect on the number of mutants. One compound induced exclusively frameshift mutations. The other mutagenic compounds induced frameshift mutations as well as base-pair substitutions. Seven compounds were more mutagenic for the repair-proficient than for the repair-deficient strains; only one showed the opposite effect. Apparently, for mutagenicity testing of Pt compounds, repair-proficient strains are more sensitive indicators. The differences in response of the various strains toward the compounds suggest the formation of different DNA lesions and(or) a selective action of repair processes on these lesions. In general, a good qual. correlation was observed between prophage-inducing capacity, mutagenicity in bacterial and mammalian cells and antitumor activity.

Although many compounds look similar to this compound(15227-42-6)Application In Synthesis of cis-Dichlorobis(pyridine)platinum(II), numerous studies have shown that this compound(SMILES:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: cis-Dichlorobis(pyridine)platinum(II)(SMILESS: [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2,cas:15227-42-6) is researched.Application In Synthesis of cis-Dichlorobis(pyridine)platinum(II). The article 《Rotation and conformation of purine ligands in cis-bis(6-oxopurine)platinum compounds》 in relation to this compound, is published in Inorganica Chimica Acta. Let’s take a look at the latest research on this compound (cas:15227-42-6).

cis-[PtL2L12]2+ (L = guanosine, 9-methylhypoxanthine, L1 = Me-substituted 1,3-propanediamines, py, α-picoline, 2,2′-bipyridine, 1,2-bis(pyridin-2-yl)ethane) were prepared and studied by NMR. Rotation of L about their Pt-N7 bonds is fast on the NMR time scale, when no Me groups are present on the nitrogens of the 1,3-propanediamine ligands. Rotation is slow when 2 Me groups are present on 1 N of a 1,3-propanediamine chelate. A single Me group on a N hardly seems to interfere with this rotation. Coordinated pyridines do not hinder rotation. In compounds containing 2-methylpyridine ligands, the rotation of the pyridines is slow at room temperature, but becomes fast at higher temperatures Rotation of L, however, is fast on the NMR time scale from -30 to +90°. In compounds containing 1,2-bis(pyridin-2-yl)ethane, rotation of L is slow at low temperatures, but becomes fast at room temperature Furthermore, the results obtained with these compounds show that the purines are preferentially oriented in a head-to-tail arrangement.

Although many compounds look similar to this compound(15227-42-6)Category: tetrahydroisoquinoline, numerous studies have shown that this compound(SMILES:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Marcelis, A. T. M.; Van der Veer, J. L.; Zwetsloot, J. C. M.; Reedijk, J. researched the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ).Application In Synthesis of cis-Dichlorobis(pyridine)platinum(II).They published the article 《Rotation and conformation of purine ligands in cis-bis(6-oxopurine)platinum compounds》 about this compound( cas:15227-42-6 ) in Inorganica Chimica Acta. Keywords: platinum purine diamine pyridine NMR; guanosine platinum diamine pyridine NMR; methylhypoxanthine platinum diamine pyridine NMR; conformation purine platinum complex NMR. We’ll tell you more about this compound (cas:15227-42-6).

cis-[PtL2L12]2+ (L = guanosine, 9-methylhypoxanthine, L1 = Me-substituted 1,3-propanediamines, py, α-picoline, 2,2′-bipyridine, 1,2-bis(pyridin-2-yl)ethane) were prepared and studied by NMR. Rotation of L about their Pt-N7 bonds is fast on the NMR time scale, when no Me groups are present on the nitrogens of the 1,3-propanediamine ligands. Rotation is slow when 2 Me groups are present on 1 N of a 1,3-propanediamine chelate. A single Me group on a N hardly seems to interfere with this rotation. Coordinated pyridines do not hinder rotation. In compounds containing 2-methylpyridine ligands, the rotation of the pyridines is slow at room temperature, but becomes fast at higher temperatures Rotation of L, however, is fast on the NMR time scale from -30 to +90°. In compounds containing 1,2-bis(pyridin-2-yl)ethane, rotation of L is slow at low temperatures, but becomes fast at room temperature Furthermore, the results obtained with these compounds show that the purines are preferentially oriented in a head-to-tail arrangement.

Although many compounds look similar to this compound(15227-42-6)Application In Synthesis of cis-Dichlorobis(pyridine)platinum(II), numerous studies have shown that this compound(SMILES:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of the American Chemical Society called Stereospecific synthesis of cyclobutanol derivatives using a 5 minus 1 methodology and platinum(II), Author is Stewart, Frederick F.; Jennings, P. W., which mentions a compound: 15227-42-6, SMILESS is [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2, Molecular C10H10Cl2N2Pt, SDS of cas: 15227-42-6.

Cycloaddition reaction of the carbene N2CHCO2Et to norbornene in the presence of Rh(II) gave 95% tricyclic esters I (R = CO2Et), which were reduced with LiAlH4 to give 63% I (R = CH2OH) (II). Kinetic resolution of II by oxidative insertion with Pt(py)2Cl2 gave 93% complex III (R = CH2OH) and its isomer, which underwent stereospecific acid-catalyzed ring expansion to give 70-80% complexes IV (R1 = H, Me, CHO; L = py) and their isomers. Ligand substitution with P(OMe)3 gave 100% IV [L = P(OMe)3], which underwent reductive elimination on heating to give 80-90% III (R = OR1).

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Formula: C10H10Cl2N2Pt. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Multinuclear solid-state NMR of square-planar platinum complexes – Cisplatin and related systems. Author is Lucier, Bryan E. G.; Reidel, Alex R.; Schurko, Robert W..

Multinuclear solid-state NMR (SSNMR) experiments were performed on cisplatin and four related square-planar compounds The wideband uniform rate smooth truncation-Carr-Purcell-Meiboom-Gill (WURST-CPMG) pulse sequence was used in NMR experiments to acquire 195Pt, 14N, and 35Cl ultra-wideline NMR spectra of high quality. Standard Hahn-echo and magic-angle spinning 195Pt NMR experiments are also performed to refine extracted chem. shielding (CS) tensor parameters. Platinum magnetic shielding (MS) tensor orientations are calculated using both plane-wave d. functional theory (DFT) and standard DFT methods. The tensor orientations are highly constrained by mol. symmetry elements, but also influenced to some degree by intermol. interactions. 14N WURST-CPMG experiments were performed on three compounds and elec. field gradient (EFG) parameters (the quadrupolar coupling constant, Cq, and the asymmetry parameter, ηq) are reported. First principles calculations of the 14N EFG tensor parameters and orientations and affirm their dependence on the local hydrogen bonding environment. 35Cl WURST-CPMG experiments on cisplatin and transplatin are reported, using two different static magnetic fields to extract EFG and CS tensor parameters, and 35Cl EFG tensor magnitudes and orientations are predicted using 1st principles calculations Transverse (T2) relaxation data for all nuclei were used to study heteronuclear dipolar relaxation mechanisms, as well as the nature of the local hydrogen bonding environments.

Although many compounds look similar to this compound(15227-42-6)Formula: C10H10Cl2N2Pt, numerous studies have shown that this compound(SMILES:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Category: tetrahydroisoquinoline. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Ruthenium(III) 2-(aminofluoreneazo)phenolate complexes: Synthesis, characterization, catalytic activity in amidation reaction and Fluorescence quenching studies. Author is Thirumal, Muniyappan; Venkattappan, Anbazhagan; Venkatachalam, Galmari.

Ru(III)2-(aminofluoreneazo)phenolate complexes [RuCl(PPh3)2(L1-5)] (1-5) (L = 2-(aminofluoreneazo)phenolate ligands) were synthesized. The characterization of the synthesized complexes was accomplished by elemental anal., spectroscopic (FTIR, UV-visible, Fluorescence and EPR) and ESI-MS techniques. The catalytic performance of one of the synthesized complexes 3 for the amidation of aldehyde in the presence of NaHCO3/NH2OH·HCl was evaluated. The fluorescence emission of [RuCl(PPh3)2(L2)] (2) and [RuCl(PPh3)2(L3) (3)] are effectively quenched by 1,4-benzoquinone and 1,4-naphthoquinone in MeCN medium.

Although many compounds look similar to this compound(1452-77-3)Category: tetrahydroisoquinoline, numerous studies have shown that this compound(SMILES:O=C(N)C1=NC=CC=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem