Month: April 2022

Vereshchagin, Anatoly N.; Frolov, Nikita A.; Pakina, Anna S.; Hansford, Karl A.; Egorov, Mikhail P. published an article about the compound: 1-Bromoundecane( cas:693-67-4,SMILESS:CCCCCCCCCCCBr ).Synthetic Route of C11H23Br. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:693-67-4) through the article.

Novel five bispyridinium salts based on a naphthalene-2,7-diylbis(oxy) spacer were synthesized. The obtained compounds showed stronger biol. activity against five strains of bacteria and two fungi as compared to modern biocides such as cetylpyridinium chloride, chlorhexidine bigluconate, 1-decyl-3-(4-(4-[(1-decylpyridin-1-ium-3-yl)oxy]phenyl)phenoxy)pyridin-1-ium dibromide, etc. used in the pharmaceutical market.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Shirani, Mahboube; Akbari-adergani, Behrouz; Jazi, Masoud Boroumand; Akbari, Ali published an article about the compound: Picolinamide( cas:1452-77-3,SMILESS:O=C(N)C1=NC=CC=C1 ).Synthetic Route of C6H6N2O. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1452-77-3) through the article.

Ultrasound-assisted magnetic nanofluid-based liquid-phase microextraction was coupled to GC-MS in a method for simultaneous determination of the pyrethroid insecticides permethrin, deltamethrin, and cypermethrin. A highly efficient extraction solvent called “”magnetic nanofluid (MNF)”” is introduced for preconcentration of pyrethroids. The MNF consists of magnetic multiwalled carbon nanotubes (MMWCNTs) and deep eutectic solvent. Following microextraction, the MNF was detached by an external magnet from the medium without the need for centrifugation. 2-Pyridinecarboxamide, choline chloride, and anhydrous ferric chloride were used for the synthesis of the deep eutectic solvent. The effects of pH value, volume of MNF, sonication time, sample volume, and ionic strength, type and amount of back extraction solvent were investigated. Under optimum conditions of MNF volume of 50μL, time of 5 min, 100μL acetone as back extraction solvent, NaCl concentration of 1 mol.L-1 and sample volume of 30 mL, the detection limits are 2.8, 2.7 and 2.0 ng.mL-1 for permethrin, deltamethrin and cypermethrin, resp. The linear response ranges are between 0.01 and 250 ng.mL-1, and relative standard deviations (for n = 7) are 3.5, 3.2 and 2.8%. The method was successfully applied to the determination of trace levels of permethrin, deltamethrin and cypermethrin in (spiked) milk samples.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Related Products of 15227-42-6. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Cytostatic trans-platinum(II) complexes. Author is Farrell, Nicholas; Ha, Tam T. B.; Souchard, Jean Pierre; Wimmer, Franz L.; Cros, Suzy; Johnson, Neil P..

The unusual cytostatic properties of trans-Pt(II) complexes of pyridine, trans-[PtCl2L2] (L = pyridine, 4-methylpyridine), are reported. The complexes demonstrate increased cytostatic activity to L1210 leukemia cells over the cis-pyridine analogs and had activity equivalent to that of cisplatin. The results have implications for the design of structurally novel Pt antitumor agents.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Computed Properties of C6H6N2O. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Ionic liquid catalysed aerobic oxidative amidation and thioamidation of benzylic amines under neat conditions. Author is Joshi, Abhisek; Kumar, Rahul; Semwal, Rashmi; Rawat, Deepa; Adimurthy, Subbarayappa.

Tetrabutylammonium hydroxide (TBAOH) was discovered as a highly efficient and green catalyst for aerobic oxidation of the α-methylene carbon of primary amines as well as benzylic groups RCH2NH2 (R = Ph, pyren-1-yl, thiophene-2-yl, etc.) into the corresponding amides RC(O)NH2 and ketones R1C(O)C6H5 [R1 = Ph, pyridin-2-yl, C6H5C(O)] and 9H-fluoren-9-one under neat conditions. Ionic liquid TBAOH catalyzed aerobic oxidation of benzyl amines to benzamides and with elemental sulfur was described; and the corresponding benzylbenzothioamides RC(S)NHCH2R were obtained under metal-free, oxidant-free and base-free conditions. Applicability at the gram scale for the synthesis of the desired amides/ketones is also demonstrated with the present protocol.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole, is researched, Molecular C18H11Cl2N3O2S, CAS is 882562-40-5, about Targeting transcription regulation in cancer with a covalent CDK7 inhibitor.Recommanded Product: 882562-40-5.

Tumor oncogenes include transcription factors that co-opt the general transcriptional machinery to sustain the oncogenic state, but direct pharmacol. inhibition of transcription factors has so far proven difficult. However, the transcriptional machinery contains various enzymic cofactors that can be targeted for the development of new therapeutic candidates, including cyclin-dependent kinases (CDKs). Here the authors present the discovery and characterization of a covalent CDK7 inhibitor, THZ1, which has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7. Cancer cell-line profiling indicates that a subset of cancer cell lines, including human T-cell acute lymphoblastic leukemia (T-ALL), have exceptional sensitivity to THZ1. Genome-wide anal. in Jurkat T-ALL cells shows that THZ1 disproportionally affects transcription of RUNX1 and suggests that sensitivity to THZ1 may be due to vulnerability conferred by the RUNX1 super-enhancer and the key role of RUNX1 in the core transcriptional regulatory circuitry of these tumor cells. Pharmacol. modulation of CDK7 kinase activity may thus provide an approach to identify and treat tumor types that are dependent on transcription for maintenance of the oncogenic state.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

COA of Formula: C11H23Br. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-Bromoundecane, is researched, Molecular C11H23Br, CAS is 693-67-4, about Synthesis and Docking Study of N-(Cinnamoyl)-N’-(substituted)acryloyl Hydrazide Derivatives Containing Pyridinium Moieties as a Novel Class of Filamentous Temperature-Sensitive Protein Z Inhibitors against the Intractable Xanthomonas oryzae pv. oryzae Infections in Rice. Author is Zhou, Xiang; Feng, Yu-Mei; Qi, Pu-Ying; Shao, Wu-Bin; Wu, Zhi-Bing; Liu, Li-Wei; Wang, Yi; Ma, Hao-Dong; Wang, Pei-Yi; Li, Zhong; Yang, Song.

A series of novel N-(cinnamoyl)-N’-(substituted)acryloyl hydrazide derivatives containing pyridinium moieties I•X- [n = 4-11; R = Ph, 4-FC6H4, 2-thienyl, etc.; X = Br, I] were designed, and the anti-Xoo activity was determined The bioassay results showed that compound I•Br- [n = 10; R = Ph; X = Br] had excellent anti-Xoo activity (EC50 = 0.99 mg L-1) in vitro and distinct curative activity (63.2% at 200 mg L-1) in vivo. Further studies revealed that these designed compounds were XooFtsZ inhibitors, validating by the reduced GTPase activity of recombinant XooFtsZ, the non-filamentous XooFtsZ assembly observed in the TEM images, and the prolonged Xoo cells from the fluorescence patterns. Computational docking studies showed that compound I•Br- [n = 10; R = Ph; X = Br] had strong interactions with ASN34, GLN193, and GLN197 residues located in the α helix regions of XooFtsZ. The present study demonstrated the developed FtsZ inhibitors could serve as agents to control Xoo-induced infections.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: D-Alanine methylamide hydrochloride, is researched, Molecular C4H11ClN2O, CAS is 61302-99-6, about New Amino Acids for the Topographical Control of Peptide Conformation: Synthesis of All the Isomers of α,β-Dimethylphenylalanine and α,β-Dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid of High Optical Purity.Name: D-Alanine methylamide hydrochloride.

The synthesis of all four diastereoisomers of α,β-dimethylphenylalanine, H2NCMe(CHMePh)CO2H, (4) as well as those of α,β-dimethyl-1,2,3,4,-tetrahydroisoquinoline-3-carboxylic acid (I and II) have been accomplished in high yield and high optical purity. Mol. mechanics calculations on the Nα-acetyl and N-methylcarboxamide derivatives of (3R,4R)-I and (3R,4S)-II indicate large and moderate energy stabilization for the gauche(-) but not the gauche(+) side-chain conformers of (3R,4S)-II and (3R,4R)-I, resp. By symmetry rules, the same holds for (3S,4R)-II and (3S,4S)-I, resp. Thus, these amino acids are potential building blocks for the topog. design of peptides (W. M. Kazmierski et al., 1991) by providing acylated 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives in which a gauche(-) and not a gauche(+) side-chain conformation is energetically more stable for the L-amino acid. Synthetic details and implications of these new amino acids for peptide and protein design are discussed.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: D-Alanine methylamide hydrochloride, is researched, Molecular C4H11ClN2O, CAS is 61302-99-6, about New Amino Acids for the Topographical Control of Peptide Conformation: Synthesis of All the Isomers of α,β-Dimethylphenylalanine and α,β-Dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid of High Optical Purity, the main research direction is stereoisomer dimethylphenylalanine asym synthesis conformation; phenylalanine dimethyl stereoisomer preparation conformation; isoquinolinecarboxylic acid dimethyltetrahydro stereoisomer conformation.Safety of D-Alanine methylamide hydrochloride.

The synthesis of all four diastereoisomers of α,β-dimethylphenylalanine, H2NCMe(CHMePh)CO2H, (4) as well as those of α,β-dimethyl-1,2,3,4,-tetrahydroisoquinoline-3-carboxylic acid (I and II) have been accomplished in high yield and high optical purity. Mol. mechanics calculations on the Nα-acetyl and N-methylcarboxamide derivatives of (3R,4R)-I and (3R,4S)-II indicate large and moderate energy stabilization for the gauche(-) but not the gauche(+) side-chain conformers of (3R,4S)-II and (3R,4R)-I, resp. By symmetry rules, the same holds for (3S,4R)-II and (3S,4S)-I, resp. Thus, these amino acids are potential building blocks for the topog. design of peptides (W. M. Kazmierski et al., 1991) by providing acylated 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives in which a gauche(-) and not a gauche(+) side-chain conformation is energetically more stable for the L-amino acid. Synthetic details and implications of these new amino acids for peptide and protein design are discussed.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Luminescence properties of some platinum(II) complexes. Counter-ion and molecular geometry effects, published in 1973, which mentions a compound: 15227-42-6, Name is cis-Dichlorobis(pyridine)platinum(II), Molecular C10H10Cl2N2Pt, SDS of cas: 15227-42-6.

Reflectance and luminescence spectra, and emission lifetimes of 14 charged and neutral Pt(II) crystalline complexes are reported. The lifetimes (in the range of some tens of μsec) indicate that the emissions are due to a spin-forbidden process. On the basis of spectral correlations, the phosphorescence is tentatively identified as due to the lowest d-d ligand field transition when the bonding of the ligand is essentially σ in character, and to a π* → d charge-transfer transition for those complexes in which the ligands themselves have π orbital systems. Both the radiative (kr) and nonradiative (kn) rate constants are sensitive to changes in mol. geometry (cis,trans isomers) and counter-ions. By assuming unitary efficiency for the intersystem crossing to the emitting state, the counter-ion appears to predominantly affect kn through vibrational coupling of the chromophore with the lattice. For the cis forms, both kr and kn are affected in a complex manner, with metal-metal interactions playing an important role. For the trans forms, however, the constancy of the quantum yield with respect to temperature suggests that kn is negligible in comparison to kr, and therefore the trans chromophores behave as isolated systems within the crystalline lattice.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Category: tetrahydroisoquinoline. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 4-Amino-2-(tert-butyl)pyrimidine, is researched, Molecular C8H13N3, CAS is 114362-20-8, about σ-Adduct formation between amines and liquid ammonia. Part 47. On the Chichibabin amination of pyrimidine and N-alkylpyrimidinium salts using liquid ammonia/potassium permanganate. Author is Buurman, Dick J.; Van der Plas, Henk C..

4-Aminopyrimidines I (R1 = C1-4 alkyl) and iminodihydropyrimidines II (R2 = Et, CHMe2) were prepared 2-Alkylpyrimidines were treated with KNH2-NH3-KMnO4 to give I. The reaction of 1,2-diethylpyrimidinium fluoroborate with NH3-KMnO4 gave II (R2 = Et).

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem