Month: April 2022

Tahtaci, Hakan; Aydin, Gozde published an article about the compound: 1-Bromoundecane( cas:693-67-4,SMILESS:CCCCCCCCCCCBr ).COA of Formula: C11H23Br. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:693-67-4) through the article.

In this study, a new series of substituted 1,3,4-thiadiazol-2(3H)-one derivatives I [R = Et, CH2CH=CH2, cyclohexylmethyl, etc.] was synthesized in yields ranging from 42 to 70% via reaction of alkyl bromides with 1-(4-chlorophenyl)-2-((5-methyl-1,3,4-thiadiazol-2-yl)thio)ethanol with an interesting mechanism that involved internal nucleophilic substitution followed by an SN2-type nucleophilic substitution. First, 1-(4-chlorophenyl)-2-((5-methyl-1,3,4-thiadiazol-2-yl)thio)ethanone was synthesized from the reaction of 5-methyl-1,3,4-thiadiazole-2-thiol with 2-bromo-1-(4-chlorophenyl)ethanone which underwent reduction to afford 1-(4-chlorophenyl)-2-((5-methyl-1,3,4-thiadiazol-2-yl)thio)ethanol. The advantages of this protocol were synthesis of target compounds under mild conditions using simple synthetic methods and obtaining them without phosgene.

The article 《A simple and efficient approach for the synthesis of a novel class aliphatic 1,3,4-thiadiazol-2(3H)-one derivatives via intramolecular nucleophilic substitution reaction》 also mentions many details about this compound(693-67-4)COA of Formula: C11H23Br, you can pay attention to it, because details determine success or failure

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Ahmad, Kaleem; Dixit, Vivek published the article 《Quantum mechanical study of coordination ability of amides using eigen value parameters》. Keywords: amide eigen value MO character.They researched the compound: Picolinamide( cas:1452-77-3 ).Recommanded Product: Picolinamide. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1452-77-3) here.

It is well known fact that the bonding occurs at oxygen atom in the Amides compounds In order to prove this fact we have considered eighteen Amides compounds Present study deals to calculate their Eigen value using Quantum Mech. descriptors via Cache software. With the help of Eigen values, the concentrations of electrons on oxygen and nitrogen atoms of Amides compounds have been calculated In Amides compounds, the sum of contributions of p-orbitals of oxygen atom in the formation of MOs is smaller as compared to other atoms. This indicates that the bonding takes place at oxygen atom.

The article 《Quantum mechanical study of coordination ability of amides using eigen value parameters》 also mentions many details about this compound(1452-77-3)Recommanded Product: Picolinamide, you can pay attention to it, because details determine success or failure

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-Bromoundecane( cas:693-67-4 ) is researched.Application of 693-67-4.Liu, Yixian; Xu, William Z.; Charpentier, Paul A. published the article 《Reactivity Ratios of MMA and N,N-Dimethyl-N-{2-[(2-methylprop-2-enoyl)oxy]ethyl}undecane-1-aminium Bromide in Thermal and UV Initiation Copolymerization》 about this compound( cas:693-67-4 ) in Industrial & Engineering Chemistry Research. Keywords: reactivity MMA dimethylmethylpropenoyloxyethylundecaneaminium bromide copolymerization. Let’s learn more about this compound (cas:693-67-4).

Reactivity ratios for the copolymerization of Me methacrylate (MMA) and a quaternary ammonium compound (QAC) N,N-dimethyl-N-{2-[(2-methylprop-2-enoyl)oxy]ethyl}undecane-1-aminium bromide (dMEMUABr) were measured for the first time by using a thermal initiator azobisisobutyronitrile (AIBN) in deuterated DMSO (DMSO-d6) and deuterated chloroform (CDCl3) and a photo initiator 2-hydroxy-2-methylpropiophenone (HMP) under UV irradiation in CDCl3, resp. The consumption profiles for monomer in the thermal initiation copolymerization were monitored by in-situ 1H NMR while the data were analyzed by the Meyo-Lewis, Kelen-Tudos, and Meyer-Lowry methods, showing that the reactivity ratio of dMEMUABr is lower than that of MMA in DMSO-d6 but much higher in CDCl3. The significantly different reactivity ratios of dMEMUABr in DMSO-d6 from that in CDCl3 are attributed to micelle formation. These findings enable addnl. flexibility in the design and development of antimicrobial poly(MMA-co-dMEMUABr) coatings with desired copolymer chain sequence.

The article 《Reactivity Ratios of MMA and N,N-Dimethyl-N-{2-[(2-methylprop-2-enoyl)oxy]ethyl}undecane-1-aminium Bromide in Thermal and UV Initiation Copolymerization》 also mentions many details about this compound(693-67-4)Application of 693-67-4, you can pay attention to it, because details determine success or failure

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Ha, T. B. T.; Souchard, J. P.; Wimmer, F. L.; Johnson, N. P. published an article about the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6,SMILESS:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2 ).Formula: C10H10Cl2N2Pt. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:15227-42-6) through the article.

The coupling constants 3J(Pt-H) of Pt(Xpy)2Z2 and Pt(Xpy)(DMSO)I2 (Xpy = py and its 4-Me, 3,5-Me, 4-Cl, 4-CN, 4-HOCH2, 4-AcO derivatives; Z = Cl, I, Br, ONO2) were recorded. The 3J(Pt-H) values of the cis complexes are 42 ± 2 Hz, while those of the trans derivatives are 31.5 ± 2.5 Hz. 2J(Pt-H) of [Pt(XNH2)2Z2] (X = Me, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl; Z = Cl, I, ONO2) were recorded. The 2J(Pt-H) values of the cis complexes are 66.5 ± 1.5z, those of the trans derivatives are 58 ± 2 Hz. Measurements of Pt-H coupling constants is a rapid method of identifying the cis and the trans isomers of Pt(II) complexes.

The article 《Determination of cis-trans isomers of amine and pyridine platinum(II) complexes by J(Pt-H) coupling constants》 also mentions many details about this compound(15227-42-6)Formula: C10H10Cl2N2Pt, you can pay attention to it, because details determine success or failure

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Product Details of 693-67-4. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1-Bromoundecane, is researched, Molecular C11H23Br, CAS is 693-67-4, about Synthesis and pancreatic lipase inhibitory activities of some 1,2,4-triazol-5(3)-one derivatives. Author is Ozdemir, Yusuf; Bekircan, Olcay; Baltas, Nimet; Mentese, Emre.

In this study, starting from 4-amino-5-(4-chlorobenzyl)-2,4-dihydro-3H-1,2,4-triazole-3-one, the 4-Amino-5-(4-chlorobenzyl)-2-undecyl-2,4-dihydro-3H-1,2,4-triazol-3-one was first synthesized and this compound was converted to Schiff base derivatives I [R = 4-F, 4-Cl, 2,4-di-F, 2,4-di-Cl, 2-F-4-Cl]. In the second step of the study, the 2-[3-(4-chlorobenzyl)-5-oxo-1-undecyl-1,5-dihydro-4H-1,2,4-triazole-4-yl]-acetohydrazide, which was used as a key product in the synthesis of many heterocyclic compounds was synthesized in four steps, and then this compound was converted into methylidene acetohydrazide II [R = 4-F, 4-Cl, 2,4-di-F, 2,4-di-Cl, 2-F-4-Cl], thiosemicarbazide III [R2 = Me, Et, Ph, Bn, 4-ClC6H4], and 1,2,4-triazole-5-thione IV [R2 = Me, Et, Ph, Bn, 4-ClC6H4; R3 = H] derivatives Also, in the last part of the study, 1,2,4-triazole-5-thione derivatives were changed into Mannich bases IV [R2 = Me, Et, Ph, Bn, 4-ClC6H4; R3 = (4-phenylpiperazin-1-yl)methyl] bearing a 4-phenylpiperazine ring. These new compounds I, II, III and IV were tested with regard to pancreatic lipase (PL) inhibition activity, and compound I [R = 4-Cl, 2,4-di-Cl], II [R = 2,4-di-Cl], III [R2 = Ph] and IV [R2 = Ph; R3 = H] showed a considerable anti-lipase activity at various concentrations The activity of compounds II [R = 4-Cl] (IC50 = 1.45 ± 0.12μM) was the highest in terms of IC50, comparable to that of orlistat, a well-known PL inhibitor used as an antiobesity drug.

The article 《Synthesis and pancreatic lipase inhibitory activities of some 1,2,4-triazol-5(3)-one derivatives》 also mentions many details about this compound(693-67-4)Product Details of 693-67-4, you can pay attention to it, because details determine success or failure

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

SDS of cas: 15227-42-6. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Antiproliferative activity of some cis-/trans-platinum(II) complexes on HeLa cells. Author is Arandjelovic, S.; Tesic, Z.; Juranic, Z.; Radulovic, S.; Vrvic, M.; Potkonjak, B.; Ilic, Z..

Platinum(II) complexes [PtA2X2], where A is ligand: ammonia (NH3), pyridine (Py); and X is ligand: chloride ion (CI-), bromide ion (Br-), iodide ion (I-), thiocyanato ion (SCN-); four compounds have different structural formulas ([Pt(NH2OH)2(NH3)2]Cl2), and cis-/trans-Pt(Gly)2, where Gly is bidentate glycinato ligand were examined for their antiproliferative activity in HeLa cells. Results of the MTT assay, showed that six cis- and one trans-platinum(II) complexes exhibited cytotoxicity (IC50) ranging between 5 and 33 μM. Most of the cis-platinum(II) isomers caused significant alteration of cell cycle phases progression, and induced apoptosis in degree that varied among different compounds, as evaluated using flowcytometry and morphol. study. Spectrophotometric anal. (AAS) indicated that there is no correlation between intracellular platinum(II) accumulation and cytotoxicity of tested complexes.

The article 《Antiproliferative activity of some cis-/trans-platinum(II) complexes on HeLa cells》 also mentions many details about this compound(15227-42-6)SDS of cas: 15227-42-6, you can pay attention to it, because details determine success or failure

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 693-67-4, is researched, SMILESS is CCCCCCCCCCCBr, Molecular C11H23BrJournal, Materials Letters called A selectable approach for polarity-fixed and polarity-controllable polymer films with hexagonal columnar structures, Author is Ohno, Takaya; Nonoshita, Sho; Akiyama, Azumi; Kohri, Michinari; Taniguchi, Tatsuo; Kishikawa, Keiki, the main research direction is polarity controllable polymer film hexagonal columnar structure; column polymerized aligned parallel applied elec field LC.Related Products of 693-67-4.

Electroresponsive columnar liquid crystalline urea compounds, N,N’-bis(3,4,5-trialkyloxyphenyl)ureas I and II (1 and 2, resp. ) possessing six and four terminal double bonds, were photopolymerized by UV irradiation in the liquid crystal phases to give polymerized compounds, labeled P-1-Colh and P-2-Colh, that possessed a hexagonal columnar structure. Furthermore, the photo polymerization of 1 and 2 sandwiched between two indium tin oxide-deposited glass plates with applying an elec. field (20 V μm-1), produced polymerized compounds, P-1-Colh-E and P-2-Colh-E, and polarized light optical microscopy clarified that the columns polymerized were aligned in parallel to the applied elec. field. In addition, by the phenomenon that polar substances absorb laser light (λ = 1064 nm) and emit second harmonic generation light (λ = 532 nm), the difference in electro-response between P-1-Colh-E and P-2-Colh-E has been revealed. The former was a polymer whose macropolarity was completely fixed, and the latter was a polymer whose macropolarity was controllable by applying an external voltage.

The article 《A selectable approach for polarity-fixed and polarity-controllable polymer films with hexagonal columnar structures》 also mentions many details about this compound(693-67-4)Related Products of 693-67-4, you can pay attention to it, because details determine success or failure

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about trans-Dichlorotetrakis(pyridine)platinum(IV) nitrate: a classical coordination compound.Product Details of 15227-42-6.

Claims that trans-[PtCl2(py)4](NO3)2 forms a covalent hydrate when dissolved in water are shown to be in error; the observed acidity of the aqueous solution is due to the presence of a small amount of a strongly acidic impurity, and all of the observed phys. and spectroscopic properties of the salt are simply interpreted in terms of classical coordination chem.

The article 《trans-Dichlorotetrakis(pyridine)platinum(IV) nitrate: a classical coordination compound》 also mentions many details about this compound(15227-42-6)Product Details of 15227-42-6, you can pay attention to it, because details determine success or failure

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ) is researched.Product Details of 15227-42-6.Webster, Lorraine K.; Deacon, Glen B.; Buxton, David P.; Hillcoat, Brian L.; James, Alison M.; Roos, Ian A. G.; Thomson, Robin J.; Wakelin, Laurence P. G.; Williams, Tracey L. published the article 《cis-Bis(pyridine)platinum(II) organoamides with unexpected growth inhibition properties and antitumor activity》 about this compound( cas:15227-42-6 ) in Journal of Medicinal Chemistry. Keywords: bispyridine platinum amide antitumor. Let’s learn more about this compound (cas:15227-42-6).

The platinum(II) organoamides [Pt(NRCH2)2L2] (L = pyridine (py), R = p-HC6F4, C6F5, p-IC6F4, p-ClC6F4, p-C6F5C6F4; L = 4-methylpyridine, R = p-HC6F4) and [Pt(NRCH2CH2NR’)(py)2] (R = p-HC6F4, R’ = C6F5, p-BrC6F4, or p-MeC6F4) inhibit the growth of murine L1210 leukemia cells in culture with ID50 values for continuous exposure in the range 0.6-2.7 μM. Representative complexes are also active against L1210 cells in 2-h pulse exposures, as well as against the cisplatin-resistant variant L1210/DDP and human colonic carcinoma cell lines HT 29 and BE. Three complexes [Pt(NRCH2)2L2] (R = p-HC6F4, C6F5, or p-IC6F4) have good activity (T/C ≥ 180%) against P388 leukemia in mice, and all other compounds tested are active except when R = p-C6F5C6F4, L = py. Although the mol. basis of the biol. activity of these complexes is not known, the observation of good activity for amineplatinum(II) compounds with no hydrogen substituents on the nitrogen donor atoms introduces a new factor in the anticancer behavior of platinum(II) complexes.

The article 《cis-Bis(pyridine)platinum(II) organoamides with unexpected growth inhibition properties and antitumor activity》 also mentions many details about this compound(15227-42-6)Product Details of 15227-42-6, you can pay attention to it, because details determine success or failure

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Horvath, Gabriela; Premkumar, Thathan; Boztas, Ali; Lee, Eunhye; Jon, Sangyong; Geckeler, Kurt E. published an article about the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6,SMILESS:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2 ).Recommanded Product: cis-Dichlorobis(pyridine)platinum(II). Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:15227-42-6) through the article.

A novel, water-soluble trans-platinum complex was synthesized by inclusion complexation with β-cyclodextrin. The complexation was confirmed by 1H NMR, FT-IR, TGA, and XRD as well as by SEM and EDX. As the precursor complex is not water-soluble, it is difficult to employ it for biol. applications. Here, we report that the encapsulation with cyclodextrin allowed to solubilize the complex to a solubility value of 1.6 mg/mL. Moreover, the cytotoxicity in vitro of the novel inclusion complex indicated a much higher activity after encapsulation.

The article 《Supramolecular Nanoencapsulation as a Tool: Solubilization of the Anticancer Drug trans-Dichloro(dipyridine)platinum(II) by Complexation with β-Cyclodextrin》 also mentions many details about this compound(15227-42-6)Recommanded Product: cis-Dichlorobis(pyridine)platinum(II), you can pay attention to it, because details determine success or failure

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem