Month: April 2022

Wang, Kaizhi; Jiang, Pengbo; Yang, Ming; Ma, Ping; Qin, Jiaheng; Huang, Xiaokang; Ma, Lei; Li, Rong published the article 《Metal-free nitrogen -doped carbon nanosheets: a catalyst for the direct synthesis of imines under mild conditions》. Keywords: transfer hydrogenation nitrile nitrogen doped carbon nanocatalyst; imine preparation amine oxidation nitrile nitrogen doped carbon nanocatalyst.They researched the compound: Picolinamide( cas:1452-77-3 ).SDS of cas: 1452-77-3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1452-77-3) here.

Herein, a highly stable, porous, multifunctional and metal-free catalyst was developed, which exhibited significant catalytic performance in the oxidation of amines and transfer hydrogenation of nitriles under mild conditions; this could be attributed to the presence of numerous active sites and their outstanding BET surface area. The obtained results showed that most of the yields of imines exceeded 90%, and the cycling performance of the catalyst could be at least seven runs without any decay in the reaction activity, which could be comparable to those of metal catalysts. Subsequently, a kinetic study has demonstrated that the apparent activation energy for the direct synthesis of imines from amines is 67.39 kJ mol-1, which has been performed to testify that the catalytic performances are rational. Via catalyst characterizations and exptl. data, graphitic-N has been proven to be the active site of the catalyst. Hence, this study is beneficial to comprehend the mechanism of action of a metal-free N-doped carbon catalyst in the formation of imines.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Recommanded Product: 15227-42-6. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Bis(pentafluorophenyl) complexes of palladium(II) and of platinum(II). Author is Uson, R.; Fornies, J.; Gimeno, J.; Espinet, P.; Navarro, R..

The preparation of 8 bis(pentafluorophenyl) complexes of Pd(II) and of Pt(II) with monodentate and bidentate N-donor ligands is described together with a preparation of a Pd(II) complex of 1,2-bis(diphenylphosphino)ethane. Assignments of cis or trans configuration are discussed which depend upon the splitting or disappearance of certain bands in ir.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 693-67-4, is researched, Molecular C11H23Br, about Room-Temperature, Deep-Red/NIR-Emissive, C3-Symmetric (n,π-conjugated) Columnar Liquid Crystals: C3h-Tris(keto-hydrazone)s, the main research direction is photoluminescent columnar discotic liquid crystal.Electric Literature of C11H23Br.

The first examples of deep-red/near-IR (NIR) photoluminescent, (n,π-conjugated) discotics, namely, C3h-tris(keto-hydrazone)s, which are the tautomers of tris(azo-enol)s, have been synthesized via a facile one-step triple azo-coupling and characterized. The n,π-resonance-assisted intramol. H-bonding, rendering planarity and shape persistence to the central core, facilitates their self-assembly into either a hexagonal columnar (Colh) phase (p6mm lattice) or a columnar rectangular (Colr) phase (p2mm lattice), over an extended thermal range including room temperature, fluorescing in the deep-red/NIR-I region. The low band gap with deep-red/NIR emission makes them ideal candidates for NIR-organic light-emitting diodes (OLEDs) and bioimaging.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ) is researched.Recommanded Product: cis-Dichlorobis(pyridine)platinum(II).Colangelo, Donato; Ghiglia, AnnaLisa; Viano, Ilario; Mahboobi, Homa; Ghezzi, AnnaRita; Cassino, Claudio; Osella, Domenico published the article 《Might telomerase enzyme be a possible target for trans-Pt(II) complexes?》 about this compound( cas:15227-42-6 ) in Journal of Inorganic Biochemistry. Keywords: trans platinum antitumor complex telomerase target. Let’s learn more about this compound (cas:15227-42-6).

Telomerase is a ribonucleoprotein polymerase that synthesizes telomeric DNA (TTAGGG) repeats. Previously, we have studied the effect on telomerase enzyme of several cis-platinum(II) complexes bearing aromatic amines as bulky carrier groups. All these complexes possess cis-geometry, according to the Cleare and Hoschele’s rule. Since recent reports have dealt with the anti-cancer activity of trans-platinum compounds, in this study we have investigated the Farrell’s prototypical trans-[Pt(Cl)2(pyridine)2], hereafter called trans-PtPy, to understand whether it may possess any anti-telomerase activity. The trans-PtPy has low water solubility and requires DMSO as co-solvent, thus making the biol. tests problematic. The effect of trans-PtPy on MCF-7 cell line concerning log-term telomerase inhibition, telomerase-related gene expression, viability, and apoptosis was evaluated. In a cell-free biochem. assay, trans-PtPy showed significant and dose-dependent inhibition of semi-purified telomerase. The bulk of data indicate that trans-PtPy acts as a non-properly selective anti-proliferative agent, although it shows an initial telomerase inhibitory effect. Telomere length reduction seems not to be the main mechanism causing the observed cell apoptosis. For comparison purpose, results on cis-[Pt(Cl)2(pyridine)2] are reported.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 4-Amino-2-(tert-butyl)pyrimidine(SMILESS: NC1=NC(C(C)(C)C)=NC=C1,cas:114362-20-8) is researched.Formula: C6H6N2O. The article 《σ-Adduct formation between amines and liquid ammonia. Part 47. On the Chichibabin amination of pyrimidine and N-alkylpyrimidinium salts using liquid ammonia/potassium permanganate》 in relation to this compound, is published in Journal of Heterocyclic Chemistry. Let’s take a look at the latest research on this compound (cas:114362-20-8).

4-Aminopyrimidines I (R1 = C1-4 alkyl) and iminodihydropyrimidines II (R2 = Et, CHMe2) were prepared 2-Alkylpyrimidines were treated with KNH2-NH3-KMnO4 to give I. The reaction of 1,2-diethylpyrimidinium fluoroborate with NH3-KMnO4 gave II (R2 = Et).

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Formula: C6H6N2O. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Arene-ruthenium(II)-phosphine complexes: Green catalysts for hydration of nitriles under mild conditions. Author is Vyas, Komal M.; Mandal, Poulami; Singh, Rinky; Mobin, Shaikh M.; Mukhopadhyay, Suman.

Three new arene-ruthenium(II) complexes were prepared by treating [{RuCl(μ-Cl)(η6-arene)}2] (η6-arene = p-cymene) dimer with tri(2-furyl)phosphine (PFu3) and 1,3,5-triaza-7-phosphaadamantane (PTA), resp. to obtain [RuCl2(η6-arene)PFu3] [Ru]-1, [RuCl(η6-arene)(PFu3)(PTA)]BF4 [Ru]-2 and [RuCl(η6-arene)(PFu3)2]BF4 [Ru]-3. All the complexes were structurally identified using anal. and spectroscopic methods including single-crystal X-ray studies. The effectiveness of resulting complexes as potential homogeneous catalysts for selective hydration of different nitriles into corresponding amides in aqueous medium and air atm. was explored. There was a remarkable difference in catalytic activity of the catalysts depending on the nature and number of phosphorus-donor ligands and sites available for catalysis. Exptl. studies performed using structural analogs of efficient catalyst concluded a structural-activity relationship for the higher catalytic activity of [Ru]-1, being able to convert huge variety of aromatic, heteroaromatic and aliphatic nitriles. The use of eco-friendly water as a solvent, open atm. and avoidance of any organic solvent during the catalytic reactions prove the reported process to be truly green and sustainable.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Mattern, I. E.; Cocchiarella, L.; Van Kralingen, C. G.; Lohman, P. H. M. published an article about the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6,SMILESS:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2 ).Reference of cis-Dichlorobis(pyridine)platinum(II). Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:15227-42-6) through the article.

Eleven Pt compounds with N donor ligands (aminocyclopentane, aminocyclohexane, pyridine, etc.), previously tested for antitumor activity, were studied for induction of prophage λ and for mutagenicity in the Ames assay, with various strains of Salmonella. The compounds included cis and trans isomers of Pt(II) and Pt(IV) complexes and were tested with and without metabolic activation. All the cis compounds elicited prophage induction, whereas the trans compounds were inactive. Mutagenicity was found only in strains containing the R factor, indicating that SOS-type repair processes are required for the conversion of initial DNA lesions into mutations. Mutation induction was also influenced by the excision-repair process. The 2 trans compounds were not, or only slightly, mutagenic; all other compounds were mutagenic in at least one strain, exhibited a 2-20-fold increase over the spontaneous background level. Addition of liver homogenate had no significant effect on the number of mutants. One compound induced exclusively frameshift mutations. The other mutagenic compounds induced frameshift mutations as well as base-pair substitutions. Seven compounds were more mutagenic for the repair-proficient than for the repair-deficient strains; only one showed the opposite effect. Apparently, for mutagenicity testing of Pt compounds, repair-proficient strains are more sensitive indicators. The differences in response of the various strains toward the compounds suggest the formation of different DNA lesions and(or) a selective action of repair processes on these lesions. In general, a good qual. correlation was observed between prophage-inducing capacity, mutagenicity in bacterial and mammalian cells and antitumor activity.

From this literature《Prophage induction and mutagenicity of a series of antitumor platinum(II) and platinum(IV) coordination complexes》,we know some information about this compound(15227-42-6)Reference of cis-Dichlorobis(pyridine)platinum(II), but this is not all information, there are many literatures related to this compound(15227-42-6).

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Devika, Neelakandan; Ananthalakshmi, Subbiah; Raja, Nandhagopal; Gupta, Gajendra; Therrien, Bruno published an article about the compound: Picolinamide( cas:1452-77-3,SMILESS:O=C(N)C1=NC=CC=C1 ).COA of Formula: C6H6N2O. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1452-77-3) through the article.

A series of mono-cationic half-sandwich rhodium(III) complexes have been synthesized in methanol using phenylhydrazone-derived ligands (L1-L6) and the starting precursor [(η5-C5Me5)2Rh2(μ-Cl)2Cl2] in a 2:1 molar ratio. The N,N’-phenylhydrazone complexes have been isolated as tetraphenylborate salts. All complexes were characterized by elemental anal., FT-IR, UV-visible, NMR spectroscopy and mass spectrometry. The mol. structure of complex [(η5-C5Me5)Rh(L1)Cl](BPh4) (1) was confirmed by single-crystal X-ray structure anal. Complex [(η5-C5Me5)Rh(L3)Cl](BPh4) (3) was used as an efficient catalyst for the amide formation reaction, with up to 99% conversion after 2 h in toluene at 110 °C in the presence of hydroxyl amine hydrochloride and sodium bicarbonate.

From this literature《Amidation of aldehydes using mono-cationic half-sandwich rhodium(III) complexes with functionalized phenylhydrazone ligands》,we know some information about this compound(1452-77-3)COA of Formula: C6H6N2O, but this is not all information, there are many literatures related to this compound(1452-77-3).

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Category: tetrahydroisoquinoline. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Coupling of CH3OH and CO2 with 2-cyanopyridine for enhanced yields of dimethyl carbonate over ZnO-CeO2 catalyst. Author is Challa, Prathap; Venkata Rao, M.; Nagaiah, P.; Nagu, A.; David Raju, B.; Rama Rao, K. S..

The present work is aimed to produce di-Me carbonate by coupling of CH3OH and CO2 with 2-cyanopyridine over ZnO-CeO2 catalysts prepared by co-precipitation method. These catalysts were characterized by XRD, TEM, UV-Vis DRS, BET surface area, CO2 and NH3-TPD techniques and applied for the titled reaction. Among the investigated catalysts 10ZnO-90CeO2 catalyst with CeO2 crystallite size 8.0 nm exhibited 96% conversion of methanol with 99% selectivity to di-Me carbonate. The superior catalytic activity is a unified effect of crystalline size of CeO2 and presence of an optimum number of acidic and basic sites. This protocol offers enhanced conversion of methanol with the simultaneous conversion of 2-cyanopyridine into 2-picolinamide by removing water mols. formed in the reaction.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Recommanded Product: cis-Dichlorobis(pyridine)platinum(II). The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about The separation of nonelectrolytic geometric isomers of platinum(II) by thin-layer chromatography. Author is Kauffman, George B.; Benson, Barrett W..

Microscope slides (75 × 25 mm.) were cleaned with detergent, rinsed in H2O, and coated with a slurry containing 1 part Silica Gel G in 3 parts of a 1:1 volume mixture of MeOH and redistilled CH2Cl2. The plates were air dried for 10-20 min. and activated for 1 hr. at 110°. Saturated solutions of the cis isomers, trans isomers, and a 1:1 by weight mixture of both Pt isomers in CH2Cl2 were applied to the plate. The plate was air dried for 2-3 min. and then developed with an ascending technique until the solvent had attained ∼6 cm. The plate was then air dried and the intense yellow-spots detected in a screw-cap jar containing I. The difference of the cis and trans migrations. ΔRf, indicated the effectiveness of separation For [Pt(Et2S)2Cl2] developed in C6H6, CH2Cl2, and 19:1 mixture of C6H6:Me2CO, ΔRf was 0.45, 0.45, and 0.45, resp. For [Pt(Bu3P)2Cl2] developed in C6H6, CH2Cl2, and a 1:1 mixture of C6H6:CH2Cl2 ΔRf was 0.95, 0.55 and 0.80, resp. For [Pt(pyridine)2Cl2] developed in CH2Cl2, 5:1 of C6H6:Me2CO Me2CO, and 5:1 of CH2Cl2:Me2CO ΔRf was 0.20, 0.45, and 0.35 resp. For [(Pr3P)2Pt2(PhS)2Cl2] developed in C6H6 and CH2Cl2 ΔRf was 0.40 and 0.45, resp. For [(Pr3P)2Pt(EtS)2Cl2] developed in CH2Cl2, 1:2 of C6H6:CH2Cl2, and C6H6 ΔRf was 0.40, 0.40, and 0.30, resp. For [Pr3P)2Pt2(p-O2NC6H4S)2Cl2] developed in CH2Cl2 and 2:1 of C6H6:Me2CO ΔRf was 0.30, 0.20, and 0.10, resp. Two (200 × 100 mm.) silica gel plates were prepared A mixture of 100 mg. cis and 100 mg. trans [Cl2Pt(PBu3)2] in CH2Cl2 were applied to the plates and developed with C6H6. The bands at Rf 0.0-0.1 and 0.85-0.10 were removed and eluted with Me2CO and CH2Cl2, resp. Evaporation yielded 91% cis isomer and 93% trans isomer. Thus, complete separation had been achieved with solvent induced isomerization.

From this literature《The separation of nonelectrolytic geometric isomers of platinum(II) by thin-layer chromatography》,we know some information about this compound(15227-42-6)Recommanded Product: cis-Dichlorobis(pyridine)platinum(II), but this is not all information, there are many literatures related to this compound(15227-42-6).

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem