Month: April 2022

Related Products of 15227-42-6. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Synthesis, characterization and cytotoxicity of some palladium(II), platinum(II), rhodium(I) and iridium(I) complexes of ferrocenylpyridine and related ligands. Crystal and molecular structure of trans-dichlorobis(3-ferrocenylpyridine)palladium(II). Author is Rajput, Jaisheila; Moss, John R.; Hutton, Alan T.; Hendricks, Denver T.; Arendse, Catherine E.; Imrie, Christopher.

The preparation of a series of ferrocenyl nitrogen donor ligands including ferrocenylpyridines, ferrocenylphenylpyridines and 1,1′-di(2-pyridyl)ferrocene is described. Coordination studies of the substituted pyridines (L) were carried out with platinum, palladium, rhodium and iridium. This resulted in the preparation of the following types of complexes: [MCl(CO)2(L)] and [M(cod)(L)2]ClO4 where M = Rh or Ir, cod = 1,5-cyclooctadiene; [M’Cl2(L)2] where M’ = Pt or Pd. The X-ray crystal structure of trans-dichlorobis(3-ferrocenylpyridine)palladium was obtained. The complexes were screened for activity against two human cancer cell lines. At least two of the complexes displayed growth inhibition similar to that of the widely used chemotherapeutic agent, cisplatin.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 114362-20-8, is researched, SMILESS is NC1=NC(C(C)(C)C)=NC=C1, Molecular C8H13N3Journal, Journal of Heterocyclic Chemistry called σ-Adduct formation between amines and liquid ammonia. Part 47. On the Chichibabin amination of pyrimidine and N-alkylpyrimidinium salts using liquid ammonia/potassium permanganate, Author is Buurman, Dick J.; Van der Plas, Henk C., the main research direction is aminopyrimidine; amination pyrimidine; iminodihydropyrimidine; pyrimidine amino.Name: 4-Amino-2-(tert-butyl)pyrimidine.

4-Aminopyrimidines I (R1 = C1-4 alkyl) and iminodihydropyrimidines II (R2 = Et, CHMe2) were prepared 2-Alkylpyrimidines were treated with KNH2-NH3-KMnO4 to give I. The reaction of 1,2-diethylpyrimidinium fluoroborate with NH3-KMnO4 gave II (R2 = Et).

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ) is researched.Synthetic Route of C10H10Cl2N2Pt.Uson, R.; Fornies, J.; Gimeno, J.; Espinet, P.; Navarro, R. published the article 《Bis(pentafluorophenyl) complexes of palladium(II) and of platinum(II)》 about this compound( cas:15227-42-6 ) in Journal of Organometallic Chemistry. Keywords: platinum pentafluorophenyl; palladium pentafluorophenyl; fluorophenylplatinum palladium penta; stereochem IR spectrum. Let’s learn more about this compound (cas:15227-42-6).

The preparation of 8 bis(pentafluorophenyl) complexes of Pd(II) and of Pt(II) with monodentate and bidentate N-donor ligands is described together with a preparation of a Pd(II) complex of 1,2-bis(diphenylphosphino)ethane. Assignments of cis or trans configuration are discussed which depend upon the splitting or disappearance of certain bands in ir.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Formula: C6H6N2O. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Discovery of a Potent Picolinamide Antibacterial Active against Clostridioides difficile. Author is Speri, Enrico; Janardhanan, Jeshina; Masitas, Cesar; Schroeder, Valerie A.; Lastochkin, Elena; Wolter, William R.; Fisher, Jed F.; Mobashery, Shahriar; Chang, Mayland.

A major challenge for chemotherapy of bacterial infections is perturbation of the intestinal microbiota. Clostridioides difficile is a Gram-pos. bacterium of the gut that can thrive under this circumstance. Its production of dormant and antibiotic-impervious spores results in chronic disruption of normal gut flora and debilitating diarrhea and intestinal infection. C. difficile is responsible for 12,800 deaths per yr in the United States. Here, we report the discovery of 2-(4-(3-(trifluoromethoxy)phenoxy)picolinamido)benzo[d]oxazole-5-carboxylate as an antibacterial with potent and selective activity against C. difficile. Its MIC50 and MIC90 (the concentration required to inhibit the growth of 50% and 90% of all the tested strains, resp.) values, documented across 101 strains of C. difficile, are 0.12 and 0.25μg/mL, resp. The compound targets cell wall biosynthesis, as assessed by macromol. biosynthesis assays and by SEM. Animals infected with a LD of C. difficile and treated with compound 1 had a similar survival compared to treatment with vancomycin, which is the frontline antibiotic used for C. difficile infection.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Mendeleev Communications called Synthesis and biological evaluation of novel bispyridinium salts containing naphthalene-2,7-diylbis(oxy) spacer, Author is Vereshchagin, Anatoly N.; Frolov, Nikita A.; Pakina, Anna S.; Hansford, Karl A.; Egorov, Mikhail P., which mentions a compound: 693-67-4, SMILESS is CCCCCCCCCCCBr, Molecular C11H23Br, Name: 1-Bromoundecane.

Novel five bispyridinium salts based on a naphthalene-2,7-diylbis(oxy) spacer were synthesized. The obtained compounds showed stronger biol. activity against five strains of bacteria and two fungi as compared to modern biocides such as cetylpyridinium chloride, chlorhexidine bigluconate, 1-decyl-3-(4-(4-[(1-decylpyridin-1-ium-3-yl)oxy]phenyl)phenoxy)pyridin-1-ium dibromide, etc. used in the pharmaceutical market.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Category: tetrahydroisoquinoline. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Crystal structures of three N-(pyridine-2-carbonyl)pyridine-2-carboxamides as potential ligands for supramolecular chemistry. Author is Xu, Xiaowen; Hoogenboom, Richard; Van Hecke, Kristof.

The synthesis and single-crystal X-ray structures of three N-(pyridine-2-carbonyl)pyridine-2-carboxamide imides, with or without F atoms on the 3-position of the pyridine rings are reported, namely, N-(pyridine-2-carbonyl)pyridine-2-carboxamide, C12H9N3O2 (1), N-(3-fluoropyridine-2-carbonyl)pyridine-2-carboxamide, C12H8FN3O2 (2), and 3-fluoro-N-(3-fluoropyridine-2-carbonyl)pyridine-2-carboxamide, C12H7F2N3O2 (3). The above-mentioned compounds were synthesized by a mild, general procedure with an excellent yield, providing straightforward access to sym. and/or asym. heterocyclic ureas. The crystal structures of 1 and 2 are isomorphous, showing similar packing arrangements, i.e. double layers of parallel (face-to-face) mols. alternating with analogous, but perpendicularly oriented, double layers. In contrast, the crystal structure of 3, containing a fluoro- group at the 3-position of both pyridine rings, shows mol. arrangements in a longitudinal, tubular manner along the c axis, with the aromatic pyridine and carbonyl/fluorine moieties facing towards each other.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Novel platinum pyridine-hydroxamic acid complexes: Synthesis, characterization, X-ray crystallographic study and nitric oxide related properties, published in 2007-10-10, which mentions a compound: 15227-42-6, mainly applied to pyridinehydroxamic acid preparation complexation platinum; crystal structure platinum pyridinehydroxamato chloro complex; platinum pyridinehydroxamato pyridinecarboxylato complex preparation; ruthenium nitrosyl chloro ethylenediaminetetraacetato complex preparation; vasorelaxation agent platinum pyridinehydroxamato pyridinecarboxylato complex; nitric oxide release platinum pyridinehydroxamato complex, Safety of cis-Dichlorobis(pyridine)platinum(II).

We describe the synthesis and characterization of a novel class of PtII and PtIV pyridine-hydroxamic acid (pyhaH) complexes of general formula cis-[PtIICl2(x-pyhaH)2] and cis-[PtIVCl4(x-pyhaH)2], resp., (where x = 3 or 4) in which the pyridine-hydroxamic acid is coordinated to the platinum ion via the pyridine nitrogen only leaving the hydroxamic acid free to potentially release cytotoxic nitric oxide (NO). The crystal structure of the PtIV derivative, cis-[PtCl4(4-pyhaH)2]·2CH3OH is reported. To establish the biol. effect of the uncoordinated hydroxamic acid moiety in the PtII compounds, the corresponding pyridinecarboxylic acid (pycaH) complexes of general formula cis-[PtIICl2(x-pycaH)2] (where x = 3 or 4) and the PtII pyridine (py) complex cis-[PtIICl2(py)2] were synthesized and served as reference standards The NO-releasing properties of each of the PtII compounds, the pyhaH and the pycaH ligands were studied. The PtII pyridine-hydroxamic acid derivatives were found to induce potent in vitro effects attributable to either NO-release from the hydroxamic acid moiety and/or stimulation of inducible nitric oxide synthase of endothelial cells.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 693-67-4, is researched, Molecular C11H23Br, about Anisotropic and magnetic properties in non-metal and non-radical organic aggregates of tri-substituted phenyl derivatives, the main research direction is alkoxy Ph imine biphenyl ester preparation anisotropic magnetic property.Reference of 1-Bromoundecane.

A new series of tri-substituted Ph derivatives containing an aromatic imine unit and biphenyl ester possessing various numbers of carbon atoms at the terminal alkoxy chain, OCnH2n+1 (n = 7-12), along with a lateral o-ethoxy substituent have been successfully prepared and characterized by CHN microanal. along with spectroscopic techniques (FTIR, 1H- and 13C-NMR). The texture observation under polarized light revealed that all the soft condensed materials exhibited an enantiotropic nematic (N) phase. The current studies have shown that the mesomorphic behavior is greatly influenced by the length of the alkoxy chains wherein the thermal stability of a tri-substituted Ph derivative will decrease if the terminal alkoxy chain is increased from n = 7 to 12. For the first time, these materials which do not possess any magnetic species in their structure, demonstrate magnetic interaction through naked eye observation as well as quant. measurement using a SQUID magnetometer.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

SDS of cas: 693-67-4. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-Bromoundecane, is researched, Molecular C11H23Br, CAS is 693-67-4, about Chalcogen bonding and liquid crystallinity: Understanding the anomalous behaviour of the 4′-(alkylthio)[1,1′-biphenyl]-4-carbonitriles (nSCB). Author is Cruickshank, Ewan; Strachan, Grant J.; Storey, John MD; Imrie, Corrie T..

The synthesis and characterization of the first eleven members of the 4′-(alkylthio)[1,1′-biphenyl]-4-carbonitriles, I [n = 1, 2, 3, etc.] was reported. All eleven members I showed monotropic liquid crystal behavior. The first six members were exclusively nematogenic, the seventh member showed nematic and smectic A phases and the higher homologues only smectic A behavior. A comparison of their transitional behavior with that of the corresponding alkyl and alkyloxy-cyanobiphenyls revealed a new pattern of behavior. Specifically, the nematic-isotropic transition temperatures showed a large decrease on passing from the methylthio to ethylthio homologues. This unexpected behavior was interpreted in terms of chalcogen bonding.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis and evaluation of 4-(2-fluoro-4-[11C]methoxyphenyl)-5-((2-methylpyridin-4-yl)methoxy)picolinamide for PET imaging of the metabotropic glutamate receptor 2 in the rat brain, published in 2019-02-01, which mentions a compound: 1452-77-3, Name is Picolinamide, Molecular C6H6N2O, Quality Control of Picolinamide.

Metabotropic glutamate receptor 2 (mGluR2) has been suggested as a therapeutic target for treating schizophrenia-like symptoms arising from increased glutamate transmission in the human forebrain. However, no reliable positron emission tomog. (PET) radiotracer allowing for in vivo visualization of mGluR2 in the human brain is currently available. In this study, we synthesized 4-(2-fluoro-4-[11C]methoxyphenyl)-5-((2-methylpyridin-4-yl)methoxy)picolinamide ([11C]1) and evaluated its potential as a PET tracer for imaging mGluR2 in the rodent brain. Compound 1, a neg. allosteric modulator (NAM) of mGluR2, showed high in vitro binding affinity (IC50: 26 nM) for mGluR2 overexpressed in human cells. [11C]1 was synthesized by O-[11C]methylation of the phenol precursor 2 with [11C]methyl iodide. After the reaction, HPLC purification and formulation, [11C]1 of 7.4 ± 2.8 GBq (n = 8) was obtained from [11C]carbon dioxide of 22.5 ± 4.8 GBq (n = 8) with >99% radiochem. purity and 70 ± 32 GBq/μmol (n = 8) molar activity at the end of synthesis. In vitro autoradiog. for rat brains showed that [11C]1 binding was heterogeneously distributed in the cerebral cortex, striatum, hippocampus, and cerebellum. This pattern is consistent with the regional distribution pattern of mGluR2 in the rodent brain. The radioactivity was significantly reduced by self- or MNI-137 (a mGluR2 NAM) blocking. Small-animal PET studies indicated a low in vivo specific binding of [11C]1 in the rat brain. The brain uptake was increased in a P-glycoprotein and breast cancer resistant protein double knockout mouse, when compared to a wild-type mouse. While [11C]1 presented limited potential as an in vivo PET tracer for mGluR2, we suggested that it can be used as a lead compound for developing new radiotracers with improved in vivo brain properties.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem