Month: April 2022

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Picolinamide( cas:1452-77-3 ) is researched.COA of Formula: C6H6N2O.Della Volpe, S.; Linciano, P.; Listro, R.; Tumminelli, E.; Amadio, M.; Bonomo, I.; Elgaher, W. A. M.; Adam, S.; Hirsch, A. K. H.; Boeckler, F. M.; Vasile, F.; Rossi, D.; Collina, S. published the article 《Identification of N,N-arylalkyl-picolinamide derivatives targeting the RNA-binding protein HuR, by combining biophysical fragment-screening and molecular hybridization》 about this compound( cas:1452-77-3 ) in Bioorganic Chemistry. Keywords: Fragment screening; Ligand-protein interaction; Molecular docking; RNA-binding proteins; SPR; STD-NMR. Let’s learn more about this compound (cas:1452-77-3).

Hu proteins are members of the RNA-binding protein (RBP) family and play a pivotal role in the regulation of post-transcriptional processes. Through interaction with selected mRNAs, RBPs regulate their function and stability; as a consequence, RBP dysregulation can cause abnormal translation of key proteins involved in several pathologies. In the past few years, this observation has sparked interest to develop new treatments against these pathologies by using small mols. able to modulate RBP activity. Among the four Hu proteins, we have directed our efforts towards the isoform HuR, which is mainly involved in cancer, inflammation and retinopathy. Aimed at developing compounds able to modulate the stability of HuR-mRNA complexes, in the present work, we applied a biophys. fragment screening by assessing a library of halogen-enriched heterocyclic fragments (HEFLibs) via Surface Plasmon Resonance (SPR) and Saturation Transfer Difference (STD) NMR to select promising fragments able to interact with HuR. One selected fragment and a few com. available congeners were exploited to design and synthesize focused analogs of compound N-(3-chlorobenzyl)-N-(3,5-dihydroxyphenethyl)-4-hydroxybenzamide (1), our previously reported hit. STD NMR spectroscopy, mol. modeling, and SPR offered further insight into the HuR-small mol. interaction and showed that fragment-based approaches represent a promising and yet underexplored strategy to tackle such unusual targets. Lastly, fluorescence polarization (FP) studies revealed the capability of the new compounds to interfere with the formation of the HuR-mRNA complex. This is, to our knowledge, the first fragment-based campaign performed on the Hu protein class, and one of the few examples in the larger RBP field and constitutes an important step in the quest for the rational modulation of RBPs and related RNA functions by small mols.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-Bromoundecane( cas:693-67-4 ) is researched.Application In Synthesis of 1-Bromoundecane.Goossens, Karel; Rakers, Lena; Heinrich, Benoit; Ahumada, Guillermo; Ichikawa, Takahiro; Donnio, Bertrand; Shin, Tae Joo; Bielawski, Christopher W.; Glorius, Frank published the article 《Anisotropic, Organic Ionic Plastic Crystal Mesophases from Persubstituted Imidazolium Pentacyanocyclopentadienide Salts》 about this compound( cas:693-67-4 ) in Chemistry of Materials. Keywords: persubstituted imidazolium pentacyanocyclopentadienide salt anisotropic organic ionic plastic crystal. Let’s learn more about this compound (cas:693-67-4).

We describe the synthesis, supramol. organization, and thermal characteristics of an unprecedented family of sym. 1,2,3,4,5-pentaalkylimidazolium ([(Cn)5i.m.]+) salts equipped with halide, nitrate, or pentacyanocyclopentadienide ([Cp(CN)5]-) counterions. Salts containing relatively small anions were obtained as low-melting solids, whereas those with [Cp(CN)5]- anions were found to be ionic liquids even below room temperature A permethylated derivative, [(C1)5i.m.][Cp(CN)5], proved to be exceptional. Upon heating, the salt self-organized into a new type of organic ionic plastic crystal (OIPC) mesophase, which was termed Mhex and whose anisotropic structure featured hexagonally ordered, rotating anionic stacks positioned within a continuum composed of disordered cations. The structure of the mesophase resembles that of classical columnar liquid-crystalline phases, despite the absence of long, flexible chains. In the Mhex phase, the cations surrounding the anionic columns effectively fulfill the role of “”softening”” structural constituents, much in the same way as flexible chains. The discovery of the novel mesophase, which displays a two-dimensional, and thus intrinsically anisotropic, lattice resulting from the rotation of entire ionic assemblies around a columnar axis, represents a new paradigm in the field of OIPCs. Relatively high ionic conductivities were measured in the Mhex phase, particularly after doping with the corresponding sodium salt, Na[Cp(CN)5], demonstrating the materials’ potential for use in electrochem. applications such as sodium-ion batteries.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Ligand effects in platinum binding to DNA. A comparison of DNA binding properties for cis- and trans-[PtCl2(amine)2] (amine = NH3, pyridine), published in 1993-09-21, which mentions a compound: 15227-42-6, Name is cis-Dichlorobis(pyridine)platinum(II), Molecular C10H10Cl2N2Pt, Electric Literature of C10H10Cl2N2Pt.

The DNA binding properties of cis- and trans-[PtCl2(pyridine)2] have been examined and compared with their NH3 analogs, cis- and trans-DDP. The presence of a planar ligand reduces the rates of DNA binding but does not greatly affect the overall conformation of CT DNA, as measured by CD spectroscopy. The sequence specificity of trans-[PtCl2(py)2] includes alternating purine-pyrimidine sequences. The sequence specificity is further different between the two pyridine isomers, and the steric effects of two cis-pyridine groups are demonstrated by the appearance of relatively few binding sites in the 49-bp duplex. The effects of the pyridine ligand are further manifested by a greatly enhanced DNA-DNA interstrand crosslinking efficiency for the trans isomer, with a cross-link per adduct frequency of between 0.14 and 0.23, depending on the rb of the sample. The unwinding of closed circular pUC19 DNA by trans-[PtCl2(pyridine)2] is also more efficient than that by either DDP isomer. In contrast, little unwinding is induced by cis-[PtCl2(pyridine)2]. These results invert the standard cis/trans structure-activity relationships observed previously for [PtCl2(NH3)2]. The results are discussed with respect to the previously demonstrated effect of activation of the trans-platinum geometry using sterically hindered ligands.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 15227-42-6, is researched, Molecular C10H10Cl2N2Pt, about Solid-phase thermal transformations of platinum(IV) aminate complexes, the main research direction is thermal reaction onium chloroplatinate; platinate chloro onium thermal reaction.Related Products of 15227-42-6.

The thermal behavior of onium chloroplatinates of the type (AH)2[PtCl6] (A = NH3, MeNH2, 0.5 en, piperidine, py, γ-picoline, NH2Ph, p-toluidine, quinoline, 0.5 2,2′-bipyridine) was studied by derivatog. and IR spectral anal. The heating of solid (AH)2[PtCl6] led to the formation of trans-PtL2Cl4 (L = py, γ-picoline) and cis-PtQ2Cl4 (Q = p-toluidine) and subsequently to the formation of cis-PtA2Cl2. When (AH)2[PtCl6] (A = piperidine) was heated (AH)2[PtCl4] was formed. These results were compared with those for the corresponding palladates.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 6-Bromo-4-methoxypicolinamide, is researched, Molecular C7H7BrN2O2, CAS is 2241400-93-9, about Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase, the main research direction is NFkappaB kinase inhibitor preparation immunomodulator.Electric Literature of C7H7BrN2O2.

NF-κB-inducing kinase (NIK) is a protein kinase central to the noncanonical NF-κB pathway downstream from multiple TNF receptor family members, including BAFF, which has been associated with B cell survival and maturation, dendritic cell activation, secondary lymphoid organ development, and bone metabolism We report herein the discovery of lead chem. series of NIK inhibitors that were identified through a scaffold-hopping strategy using structure-based design. Electronic and steric properties of lead compounds were modified to address glutathione conjugation and amide hydrolysis. These highly potent compounds exhibited selective inhibition of LTβR-dependent p52 translocation and transcription of NF-κB2 related genes. Compound 4f is shown to have a favorable pharmacokinetic profile across species and to inhibit BAFF-induced B cell survival in vitro and reduce splenic marginal zone B cells in vivo.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-Bromoundecane(SMILESS: CCCCCCCCCCCBr,cas:693-67-4) is researched.Product Details of 5451-40-1. The article 《A selectable approach for polarity-fixed and polarity-controllable polymer films with hexagonal columnar structures》 in relation to this compound, is published in Materials Letters. Let’s take a look at the latest research on this compound (cas:693-67-4).

Electroresponsive columnar liquid crystalline urea compounds, N,N’-bis(3,4,5-trialkyloxyphenyl)ureas I and II (1 and 2, resp. ) possessing six and four terminal double bonds, were photopolymerized by UV irradiation in the liquid crystal phases to give polymerized compounds, labeled P-1-Colh and P-2-Colh, that possessed a hexagonal columnar structure. Furthermore, the photo polymerization of 1 and 2 sandwiched between two indium tin oxide-deposited glass plates with applying an elec. field (20 V μm-1), produced polymerized compounds, P-1-Colh-E and P-2-Colh-E, and polarized light optical microscopy clarified that the columns polymerized were aligned in parallel to the applied elec. field. In addition, by the phenomenon that polar substances absorb laser light (λ = 1064 nm) and emit second harmonic generation light (λ = 532 nm), the difference in electro-response between P-1-Colh-E and P-2-Colh-E has been revealed. The former was a polymer whose macropolarity was completely fixed, and the latter was a polymer whose macropolarity was controllable by applying an external voltage.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Ivanov, V. B.; Chel’tsov, P. A.; Shchelokov, R. N. published the article 《Biological effect of platinum(II) complexes with two different neutral ligands of cis-[PtNH3LCl2] type》. Keywords: platinum diamine complex antimitotic; corn mitosis platinum diamine complex.They researched the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ).HPLC of Formula: 15227-42-6. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:15227-42-6) here.

The effect of Pt complexes on the growth of corn roots was studied. Two types of Pt complexes were used: (1) cis-[PtNH3LCl2], where L = DMSO, C2H4, acetonitrile, pyridine, and benzylamine, and (2) cis-[PtL2Cl2], where L = pyridine, acetonitrile, and benzylamine. The growth-inhibitory effects of all complexes were lower than that of cis-dichlorodiammine platinum [15663-27-1]. The only compound which showed distinct inhibition of mitosis was cis-[PtNH3(PhCH2NH2)Cl2] [79371-82-7]. The antimitotic activity of the Pt diamine complexes was apparently associated with the cis-diamine fragment of the mol.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Computed Properties of C11H23Br. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-Bromoundecane, is researched, Molecular C11H23Br, CAS is 693-67-4, about Incorporation of alkylthio side chains on benzothiadiazole-based non-fullerene acceptors enables high-performance organic solar cells with over 16% efficiency. Author is Cheung, Andy Man Hong; Yu, Han; Luo, Siwei; Wang, Zhen; Qi, Zhenyu; Zhou, Wentao; Arunagiri, Lingeswaran; Chang, Yuan; Yao, Huatong; Ade, Harald; Yan, He.

Y6-type non-fullerene acceptors (NFAs) with an acceptor-donor-acceptor′-donor-acceptor (A-D-A′-D-A) structure have been very popular in the field of organic solar cells (OSCs) due to their excellent performances. In this study, two novel NFAs, BTPS-4F and BTPS-4Cl were designed by incorporating undecylthio side chains into a thienothiophene moiety and connecting it to two different halogenated 2-(3-oxo-2,3-dihydroinden-1-ylidene)malononitrile end groups (2F-IC and 2Cl-IC) resp. When blended with a donor polymer, PM6, BTPS-4F-based devices achieved a high power conversion efficiency (PCE) of up to 16.2% with an open-circuit voltage (VOC) of 0.82 V, a short-circuit c.d. (JSC) of 25.2 mA cm-2 and a fill factor (FF) of 0.78, while BTPS-4Cl-based devices achieved an inferior PCE of 13.5%. This is the first time alkylthio chains are employed on Y6-like NFAs to achieve high-performance OSCs. Subsequent characterization showed that the upshifted energy level of BTPS-4F and the better intermol. packing in PM6:BTPS-4F blends are the major reasons for the enhanced performance of BTPS-4F-based devices over BTPS-4Cl-based ones. This work provides high-performance non-fullerene acceptors for OSCs and demonstrates a promising mol. design strategy that can effectively regulate their energy levels and morphol.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Electrochemical properties of MC60 (M=Pd, Pt) covered electrodes, the main research direction is electrochem property fullerene palladium platinum electrodeposited film; electrodeposition fullerene palladium platinum film; redox activity voltammetry fullerene palladium platinum electrodeposited film.SDS of cas: 15227-42-6.

The formation of electroactive films containing [60]fullerene and Pd or Pt was observed for solutions with the C60 and different metal complexes, Pd(PhCN)2Cl2, [Pd(CH3CO2)2]3, Pd(CH3CO2)2, [Pt(μ-Cl)Cl(C2H4)]2, cis-PtCl2(py)2, trans-PtCl2(py)2, and PtI2(py)2. Characterization of the film compositions by IR spectroscopy, MS and XPS shows that the films contain solely C60 and metal, as well as cations of the supporting electrolyte of the growth solution, that get incorporated during the cathodic growth process. Scanning electron micrographs of the films show that these consist mainly of spheres of ∼100 nm diameter and that the film thickness can be controlled by the number of cycles used during the growth process. The films show conductivity in the potential range of growth and this conductivity is both electronic and ionic and have thus potential application in high-d. energy storage devices.

There is still a lot of research devoted to this compound(SMILES：[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2)SDS of cas: 15227-42-6, and with the development of science, more effects of this compound(15227-42-6) can be discovered.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Hydroxy complexes of platinum(II) and palladium(II), published in 1972, which mentions a compound: 15227-42-6, Name is cis-Dichlorobis(pyridine)platinum(II), Molecular C10H10Cl2N2Pt, COA of Formula: C10H10Cl2N2Pt.

The preparation of hydroxy bridged complexes, [M2(OH)2-L4][BF4]2, where M = Pt and L = Et3P, Ph3P or py, or where M = Pd and L = Ph3P, is described. The structures are unambiguously established by ir, NMR, and x-ray crystallog. studies. The complexes are stable and resist bridge cleavage by tertiary phosphines under conditions which easily cleave analogous chloro bridged complexes.

There is still a lot of research devoted to this compound(SMILES：[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2)COA of Formula: C10H10Cl2N2Pt, and with the development of science, more effects of this compound(15227-42-6) can be discovered.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem