Month: April 2022

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1452-77-3, is researched, Molecular C6H6N2O, about Characterization of copper(II) specific pyridine containing ligands: Potential metallophores for Alzheimer’s disease therapy, the main research direction is copper zinc pyridinylmethylpicolinamide pyridinylmethylpyridinylmethylamino complex formation ESR; Amyloid β; Copper; Electron Paramagnetic Resonance spectroscopy; Metallophore; Reactive oxygen species; Speciation.Reference of Picolinamide.

Two amide group containing pyridine derivatives, N-(pyridin-2-ylmethyl)picolinamide (PMPA) and N-(pyridin-2-ylmethyl)-2-((pyridin-2-ylmethyl)amino)acetamide (DPMGA), have been investigated as potential metallo-phores in the therapy of Alzheimer’s disease. Their complex formation with Cu(II) and Zn(II) were characterized in details. Unexpectedly not only the Cu(II) but also the Zn(II) was able to induce deprotonation of the amide-NH, however, it occurred only at higher pH or at higher metal ion concentrations than the biol. conditions. At μM concentration level mono complexes (MLH-1) dominate with both ligands. Direct fluorescence and reactive oxygen species (ROS) producing measurements prove that both ligands are able to remove Cu(II) from its amyloid-β complexes (CuAβ). Correlation was also established between the conditional stability constant of the Cu(II) complexes with different ligands and their ability of inhibition of ROS production by CuAβ.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Zuma, Nonkululeko H.; Smit, Frans J.; Seldon, Ronnett; Aucamp, Janine; Jordaan, Audrey; Warner, Digby F.; N’Da, David D. published an article about the compound: 1-Bromoundecane( cas:693-67-4,SMILESS:CCCCCCCCCCCBr ).SDS of cas: 693-67-4. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:693-67-4) through the article.

To improve TB efficacy of nitrofurantoin (NFT), a series of NFT analogs I [R = Me, Et, Bn, etc.] was synthesized and evaluated in vitro for anti-mycobacterial activity against the laboratory strain, Mtb H37Rv and for potential cytotoxicity using human embryonic kidney (HEK-293) and Chinese hamster ovarian (CHO) cells. The NFT analogs showed good safety profiles, enhanced anti-mycobacterial potency, improved lipophilicity, as well as reduced protein binding affinity. Analog I [R = n-Bu] which contains an eight carbon aliphatic chain was the most active, equipotent to isoniazid (INH), a major front-line agent, with MIC90 = 0.5μM, 30-fold more potency than the parent drug, nitrofurantoin (MIC90 = 15μM), and 100-fold more selective towards mycobacteria. Therefore, compound I [R = n-Bu] was identified as a validated hit for further investigation in the urgent search for new, safe and affordable TB drugs.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Application of 1452-77-3. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Switching the secondary and natural activity of Nitrilase from Acidovorax facilis 72 W for the efficient production of 2-picolinamide. Author is Wang, Liuzhu; Jiang, Shuiqin; Sun, Yangyang; Yang, Zeyu; Chen, Zhi; Wang, Hualei; Wei, Dongzhi.

Catalytic promiscuity, or the ability to catalyze a secondary reaction, provides new opportunities for industrial biocatalysis by expanding the range of biocatalytic reactions. Some nitrilases converting nitriles to amides, referred to as the secondary activity, show great potential for amides production And our goal was exploiting the amide-forming potential of nitrilases. In this study, we characterized and altered the secondary activity of nitrilase from Acidovorax facilis 72 W (Nit72W) towards different substrates. We increased the secondary activity of Nit72W towards 2-cyanopyridine by 196-fold and created activity toward benzonitrile and p-nitrophenylacetonitrile by modifying the active pocket. Surprisingly, the best mutant, W188M, completely converted 250 mM 2-cyanopyridine to more than 98% 2-picolinamide in 12 h with a specific activity of 90 U/mg and showed potential for industrial applications. Nit72W was modified to increase its secondary activity for the amides production, especially 2-picolinamide.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Sokolenko, V. A.; Bondarenko, V. S.; Korniets, E. D.; Kovtonyuk, N. P.; Kovrova, N. B. published the article 《Solid-phase condensation of coordinated pyridine and γ-picoline in platinum(II) complexes》. Keywords: thermolysis platinum picoline pyridine complex; condensation picoline pyridine coordinated platinum.They researched the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ).Formula: C10H10Cl2N2Pt. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:15227-42-6) here.

The thermolysis of cis- and trans-[PtL2Cl2] (L = py, γ-picoline (pic)) was studied by IR and 1H NMR spectroscopy. cis-[PtL2Cl2] underwent cis-trans isomerization in the solid state at 200-220°. Thermolysis of trans-[PtL2Cl2] at 240-300° led to condensation of coordinated L to give PtL1Cl2 (L1 = 2,2′-bipyridine, 4,4′-dimethyl-2,2′-bipyridine). Thermolysis of [Pt(pic)4]Cl2 gave trans-Pt(pic)2Cl2 at 160°.

There is still a lot of research devoted to this compound(SMILES：[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2)Formula: C10H10Cl2N2Pt, and with the development of science, more effects of this compound(15227-42-6) can be discovered.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Alvarez-Bermudez, Olaia; Torres-Suay, Ana; Perez-Pla, Francisco F.; Landfester, Katharina; Munoz-Espi, Rafael researched the compound: Picolinamide( cas:1452-77-3 ).Reference of Picolinamide.They published the article 《Magnetically enhanced polymersupported ceria nanocatalysts for the hydration of nitriles》 about this compound( cas:1452-77-3 ) in Nanotechnology. Keywords: ceria nanocatalyst hydration crystallization magnetic field. We’ll tell you more about this compound (cas:1452-77-3).

The heterogeneous catalysis of the hydration of nitriles to amides is a process of great industrial relevance in which cerium(IV) oxide (also referred to as ceria) has shown an outstanding catalytic performance. The use of non-supported ceria nanoparticles is related to difficulties in the purification of the product and the recovery and recyclability of the catalyst. Therefore, in this work, ceria nanoparticles are supported on a polymer matrix either by synthesizing polymer particles by so-called Pickering miniemulsions while using ceria nanoparticles as emulsion stabilizers or, as a comparison, by in-situ crystallization on preformed polymer particles. The former strategy presents significant advantages over the latter in terms of time and consumption of resources, and it facilitates an easier scale-up of the process. In both strategies, the incorporation of a magnetoresponsive core within the polymer matrix allows the recovery and the recycling of the catalyst by simple application of a magnetic field and offers an enhancement of the catalytic efficiency.

There is still a lot of research devoted to this compound(SMILES：O=C(N)C1=NC=CC=C1)Reference of Picolinamide, and with the development of science, more effects of this compound(1452-77-3) can be discovered.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Screening a trace amount of pharmaceutical cocrystals by using an enhanced nano-spot method.HPLC of Formula: 1452-77-3.

Cocrystn. is an attractive and promising technol. that can improve the phys. properties of formulations of active pharmaceutical ingredients (APIs). We have developed a “”nano-spot method”” that can evaluate the crystalline form on the nanogram scale. In this study, the following studies were performed to obtain versatile and comprehensive improvements to the nano-spot method: modification of the sample solution, application of solvent vapor exposure to attempt the precipitation of various states of crystals, and adoption of low-frequency Raman spectroscopy. Carbamazepine was used as a model API and cocrystn. screening was examined with 12 cocrystal formers (coformers). In the case of combinations that are already known to form cocrystals, spectra similar to those of previously reported cocrystals or new spectra were obtained. It was considered that the reported cocrystals or new polymorphs were obtained. In contrast, in the case of the combination which has been reported not to form a cocrystal, the spectra were consistent with that for the phys. mixture of API and coformer, suggesting that a cocrystal also did not form in this screening. In addition, the newly adopted low-frequency Raman spectroscopy enabled the high-sensitive detection of the crystalline form.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Kumata, Katsushi; Hatori, Akiko; Yamasaki, Tomoteru; Zhang, Yiding; Mori, Wakana; Fujinaga, Masayuki; Xie, Lin; Nengaki, Nobuki; Zhang, Ming-Rong published the article 《Synthesis and evaluation of 4-(2-fluoro-4-[11C]methoxyphenyl)-5-((2-methylpyridin-4-yl)methoxy)picolinamide for PET imaging of the metabotropic glutamate receptor 2 in the rat brain》. Keywords: carbon 11 fluoromethoxyphenyl methylpyridinyl methoxypicolinamide preparation brain mGluR2 PET; In vitro autoradiography; Metabotropic glutamate receptor 2; Positron emission tomography; Radiotracer; Schizophrenia.They researched the compound: Picolinamide( cas:1452-77-3 ).Application In Synthesis of Picolinamide. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1452-77-3) here.

Metabotropic glutamate receptor 2 (mGluR2) has been suggested as a therapeutic target for treating schizophrenia-like symptoms arising from increased glutamate transmission in the human forebrain. However, no reliable positron emission tomog. (PET) radiotracer allowing for in vivo visualization of mGluR2 in the human brain is currently available. In this study, we synthesized 4-(2-fluoro-4-[11C]methoxyphenyl)-5-((2-methylpyridin-4-yl)methoxy)picolinamide ([11C]1) and evaluated its potential as a PET tracer for imaging mGluR2 in the rodent brain. Compound 1, a neg. allosteric modulator (NAM) of mGluR2, showed high in vitro binding affinity (IC50: 26 nM) for mGluR2 overexpressed in human cells. [11C]1 was synthesized by O-[11C]methylation of the phenol precursor 2 with [11C]methyl iodide. After the reaction, HPLC purification and formulation, [11C]1 of 7.4 ± 2.8 GBq (n = 8) was obtained from [11C]carbon dioxide of 22.5 ± 4.8 GBq (n = 8) with >99% radiochem. purity and 70 ± 32 GBq/μmol (n = 8) molar activity at the end of synthesis. In vitro autoradiog. for rat brains showed that [11C]1 binding was heterogeneously distributed in the cerebral cortex, striatum, hippocampus, and cerebellum. This pattern is consistent with the regional distribution pattern of mGluR2 in the rodent brain. The radioactivity was significantly reduced by self- or MNI-137 (a mGluR2 NAM) blocking. Small-animal PET studies indicated a low in vivo specific binding of [11C]1 in the rat brain. The brain uptake was increased in a P-glycoprotein and breast cancer resistant protein double knockout mouse, when compared to a wild-type mouse. While [11C]1 presented limited potential as an in vivo PET tracer for mGluR2, we suggested that it can be used as a lead compound for developing new radiotracers with improved in vivo brain properties.

There is still a lot of research devoted to this compound(SMILES：O=C(N)C1=NC=CC=C1)Application In Synthesis of Picolinamide, and with the development of science, more effects of this compound(1452-77-3) can be discovered.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 15227-42-6, is researched, SMILESS is [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2, Molecular C10H10Cl2N2PtJournal, Spectroscopy Letters called Spectral studies of some pyridine and bipyridine complexes of platinum(II), Author is Agarwala, Badri Vishal, the main research direction is platinum pyridine bipyridine spectra; UV platinum pyridine bipyridine; magnetic CD platinum pyridine bipyridine.Synthetic Route of C10H10Cl2N2Pt.

Electronic absorption spectra and magnetic CD (MCD) spectra were studied for the square planar complexes cis- and trans-Pt(py)2Cl2 and Pt(2,2′-bipyridine)Cl2(I). Detailed studies were carried out for I due to its fair solubility in many solvents and the solvent effect on its electronic spectra was investigated. The band assignments of the electronic spectra are discussed and are supported by the MCD spectra. NMR and magnetic studies were also carried out on the complexes to further elucidate their configuration. All the complexes studied are diamagnetic in conformity with their square planar arrangement.

There is still a lot of research devoted to this compound(SMILES：[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2)Synthetic Route of C10H10Cl2N2Pt, and with the development of science, more effects of this compound(15227-42-6) can be discovered.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Exceptional dual fluorescent, excited-state intramolecular proton-transfer (ESIPT) columnar liquid crystals characterized by J-stacking and large Stokes shifts, published in 2021-06-15, which mentions a compound: 693-67-4, mainly applied to phasmidic bissalicylideneaniline preparation columnar liquid crystal phase transition fluorescence, COA of Formula: C11H23Br.

Herein the synthesis, characterization, and ESIPT activity of a homologous series of novel phasmidic bis(N-salicylideneaniline) Col LCs. was reported. Optical microscopic, calorimetric and powder X-ray diffraction (XRD) studies evidence the occurrence of hexagonal columnar (Colh) phase having p6mm symmetry where the constituent slices result from the self-assembly of a pair of mesogens in a side-by-side manner facilitated by intense longitudinal π-π interactions. X-ray data confirm the absence of both directionally correlated tilting of the slices and transverse core-core interactions within the columns. Fluorescence probing clearly evidence the ESIPT occurring not only in DCM solution of the mesogens but also in their three-condensed states viz., solid, liquid crystal, and isotropic liquid phase; in general, two archetypal emission bands at ∼430 nm (weak) and ∼ 630 nm (strong) with large Stokes shifts (250-275 nm) of ESIPT phenomenon was observed The slow shift of emission maxima of the ESIPT fluorescence as a function of decreasing temperature without photoluminescence quenching coupled with the estimated tilt angle (θ) of the slices normal to the columnar axis (37 to 42°), from the XRD data, confirmed the formation of so-called Scheibe or J-aggregates. The redox activity, metal ion sensing ability, and solvatochromism of the mesogens was also investigated. The study suggests that these ESIPT Col LCs with band-gap of about 3 eV can be regarded as wide-bandgap semiconducting materials having the electronic characteristics falling between those of conventional semiconductors and insulators.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: D-Alanine methylamide hydrochloride( cas:61302-99-6 ) is researched.Recommanded Product: 61302-99-6.Okada, Yoshio; Tani, Shohei; Yawatari, Yuko; Yagyu, Masami published the article 《Synthesis of stereoisomeric alanine containing peptide derivatives》 about this compound( cas:61302-99-6 ) in Chemical & Pharmaceutical Bulletin. Keywords: alanine peptide stereoisomer; alanylalanine bactericide. Let’s learn more about this compound (cas:61302-99-6).

D-alanine derivatives and their stereoisomers and D-alanyl-D-alanine derivatives and their stereoisomers (R1-Ala-R2, R1-Ala-Ala-R2: R1 = PhCH2O2C, H; R2 = NHNH2, NHCH3, NHCH2CH2OH) were synthesized. All compounds obtained did not show antibacterial activity against Staphylococcus aureus, Sarcina lutea, Pseudomonas aeruginosa and Escherichia coli.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem