Month: April 2022

Related Products of 15227-42-6. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Pyrrole thioaldehyde complexes of nickel, palladium and platinum. Author is Pogorzelec, Peter J.; Reid, David H.; Tocher, Derek A.; Wilton-Ely, D. E. T..

The coordination chem. of the unusual, pyrrole-stabilized thioaldehyde mols., 3,5-dimethylpyrrole-2-carbothioaldehyde (HSPyMeHMe) and 3,5-dimethyl-4-ethylpyrrole-2-carbothioaldehyde (HSPyMeEtMe) was studied with nickel, palladium and platinum in preparing [M(κ2-SPyMeRMe)2] (M = Ni, Pd, Pt; R = H, Et). The structure of the cyclometalated derivative [Pd(η2-C,N-C6H4CH2-2-NMe2)(κ2-SPyMeEtME)] was determined by x-ray diffraction.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Anodic Oxidation of Dithiane Carboxylic Acids: A Rapid and Mild Way to Access Functionalized Orthoesters, published in 2020-05-15, which mentions a compound: 693-67-4, Name is 1-Bromoundecane, Molecular C11H23Br, Related Products of 693-67-4.

A new electrochem. methodol. has been developed for the preparation of a wide variety of functionalized orthoesters under mild and green conditions from easily accessible dithiane derivatives The new methodol. also offers an unprecedented way to access tri(fluorinated) orthoesters, a class of compound that has never been studied before. This provides the community with a rapid and general method to prepare libraries of functionalized orthoesters from simple and readily available starting materials.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov’t, Journal of Medicinal Chemistry called Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib, Author is Li, Yangfeng; Zhao, Jiong; Gutgesell, Lauren M.; Shen, Zhengnan; Ratia, Kiira; Dye, Katherine; Dubrovskyi, Oleksii; Zhao, Huiping; Huang, Fei; Tonetti, Debra A.; Thatcher, Gregory R. J.; Xiong, Rui, which mentions a compound: 87240-07-1, SMILESS is O=[N+](C1=CC2=C(NC=C2)C(Br)=C1)[O-], Molecular C8H5BrN2O2, HPLC of Formula: 87240-07-1.

Acquired resistance to fulvestrant and palbociclib is a new challenge to treatment of estrogen receptor pos. (ER+) breast cancer. ER is expressed in most resistance settings; thus, bromodomain and extra-terminal protein inhibitors (BETi) that target BET-amplified ER-mediated transcription have therapeutic potential. Novel pyrrolopyridone BETi leveraged novel interactions with L92/L94 confirmed by a cocrystal structure of 27 with BRD4. Optimization of BETi using growth inhibition in fulvestrant-resistant (MCF-7:CFR) cells was confirmed in endocrine-resistant, palbociclib-resistant, and ESR1 mutant cell lines. 27 was more potent in MCF-7:CFR cells than six BET inhibitors in clin. trials. Transcriptomic anal. differentiated 27 from the benchmark BETi, JQ-1, showing downregulation of oncogenes and upregulation of tumor suppressors and apoptosis. The therapeutic approach was validated by oral administration of 27 in orthotopic xenografts of endocrine-resistant breast cancer in monotherapy and in combination with fulvestrant. Importantly, at an equivalent dose in rats, thrombocytopenia was mitigated.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Parus, Anna; Homa, Jan; Radonski, Dariusz; Framski, Grzegorz; Wozniak-Karczewska, Marta; Syguda, Anna; Lawniczak, Lukasz; Chrzanowski, Lukasz published an article about the compound: 1-Bromoundecane( cas:693-67-4,SMILESS:CCCCCCCCCCCBr ).Product Details of 693-67-4. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:693-67-4) through the article.

Modern agricultural practices are often based on the use of mixtures of specific herbicides to achieve efficient crop protection. The major drawbacks of com. herbicidal formulations include the necessity to incorporate toxic surfactants and high volatility of active substances. Transformation of herbicides into herbicidal ionic liquids (HILs) seems to be a promising alternative which allows to almost completely reduce volatility due to ionic interactions. In the scope of this research, we transformed (2-methyl-4-chlorophenoxy)acetic acid (MCPA) into a quaternary ester (esterquat) with the use of derivatives of 2-dimethylaminoethanol. The obtained esterquats were later coupled with (±)-2-(4-chloro-2-methylphenoxy)propionic acid (MCPP) in the form of an anion. The combination of MCPA and MCPA is commonly applied in the UK, EU countries and also in the USA to increase the spectrum of targeted weed species. In the framework of this study, novel HILs with an esterquat moiety incorporating a long alkyl chain (C8, C9, C10, C11, C12, C14) were prepared and characterized in terms of basic physicochem. properties (solubility and volatility) as well as biodegradability. Their phytotoxicity was assessed towards cornflower (Centaurea cyanus) as a model weed and maize (Zea mays) as a crop plant. The presence of the esterquat cation contributed to satisfactory solubility in water and other low polar solvents, which eliminates the need to add exogenous adjuvants. Further experiments indicated that the tested HILs stimulated the germination stage of maize and maintained high herbicidal activity towards cornflower. No significant differences in terms of properties were observed in case of HILs which included alkyl substituents with an odd number of carbon atoms. Future studies should be focused on structural modifications in order to improve the biodegradability as well as field studies for evaluation of com. applications.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

COA of Formula: C11H23Br. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1-Bromoundecane, is researched, Molecular C11H23Br, CAS is 693-67-4, about Amphiphilic Star-Shaped Calix[4]resorcinarene as Stationary Phase for Capillary Gas Chromatography. Author is Sun, Tao; Li, Bin; Li, Yan; Zhao, Xinyu; Song, Qianqian; Jiang, Xingxing; Shuai, Xiaomin; Li, Youyang; Cai, Zhiqiang; Hu, Shaoqiang.

This work describes the separation performance of the amphiphilic star-shaped calix[4]resorcinarene (C4A-CL)(I) as the stationary phase for capillary gas chromatog. (GC). The statically coated C4A-CL capillary column exhibited medium polarity and high column efficiency of 3877 plates m-1 determined by naphthalene at 120 °C. Importantly, the C4A-CL column exhibited extremely high resolving capability for aliphatic analytes with varying polarity, including n-alkanes, esters, ketones, alcs., and bromoalkanes. In addition, the C4A-CL column exhibited high selectivity and resolving capability for positional, structural and cis-/trans-isomers. Among them, the C4A-CL column displayed advantageous resolving capability over the com. DB-17 column for aromatic amine isomers. Moreover, it was applied for the determination of isomer impurities in real samples, showing good potential in GC applications.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Recommanded Product: 15227-42-6. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Radiosensitization of EMT6 cells by four platinum complexes. Author is Teicher, Beverly A.; Rockwell, Sara; Lee, Jonathan B..

The radiosensitization of oxygenated and hypoxic exponentially growing EMT6 cells in vitro was measured. The dose modifying factors obtained with 200 and 400 μM trans-bis(2-nitroimidazole)dichloroplatinum II (NIPt) in hypoxic cells were 1.5 and 2.1, resp. For trans-bis(2-amino-5-nitrothiazole)dichloroplatinum II (Plant) under the same conditions, the dose modifying factor was 1.5 at 200 μM and 1.8 at 400 μM. Neither compound sensitized oxygenated cells when tested under similar protocols. Unlike the trans complexes, (1,2-diamino-4-nitrobenzene)dichloroplatinum II (Plato) was cytotoxic toward the hypoxic cells in the absence of x-rays. The time course of cytotoxicity for 100 μM Plato in exponentially growing cells showed rapid killing of hypoxic cells, and much less toxicity toward oxygenated cells. In radiosensitization studies, dose modifying factors of 1.6 and 2.0 were found with 200 and 400 μM Plato, resp., in hypoxic cells. The compound did not sensitize aerobic cells. The well known Pt complex cis-dipyridinedichloroplatinum II (PyPt) represents a cis-Pt heterocyclic aromatic complex that does not have a nitro-functionality. The dose modifying factor obtained with 400 μM PyPt in hypoxic cells was 1.7. On a molar basis, the nitro-functional Pt complexes appear to be more effective as hypoxic cell radiosensitizers than the corresponding free ligands.

There is still a lot of research devoted to this compound(SMILES：[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2)Recommanded Product: 15227-42-6, and with the development of science, more effects of this compound(15227-42-6) can be discovered.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Formula: C10H10Cl2N2Pt. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Thermal isomerization of complex platinum(II) compounds. Author is Kukushkin, Yu. N..

The thermal cis-trans isomerization of [PtA2I2] complexes, where A = NH3, MeNH2, EtNH2, pyridine, was studied by derivatography. The heat of isomerization is 1-7 kcal/mole. trans-[Pt(R2SO)ACl2]-type complexes melt upon heating and isomerize in the melt. The isomerization reaction proceeds through formation of a tetrahedral intermediate.

There is still a lot of research devoted to this compound(SMILES：[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2)Formula: C10H10Cl2N2Pt, and with the development of science, more effects of this compound(15227-42-6) can be discovered.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 15227-42-6, is researched, Molecular C10H10Cl2N2Pt, about Preparation and spectroscopic investigations of platinum complexes. I. Interpretation of the spectra of inverse electron transfer and ligand field transitions of platinum(II) complexes with halide and nitrogen ligands, the main research direction is platinum inverse charge transfer; halide pyridine platinum UV.Synthetic Route of C10H10Cl2N2Pt.

Inverse electron-transfer transitions of the type, 5d(Pt) → π(L), were detected in the electronic absorption spectra of cis- and trans-PtL2X2 complexes in which N-containing ligands have an internal π-electron system (L = pyridine, 3- or 4-chloropyridine, 3,5-dichloropyridine, 4-pentyl- or 4-cyanopyridine, or piperidine; X = Cl, Br, or I). In addition to ligand-field (d-d) and ligand π-π* transitions, 3 charge-transfer transitions were distinguished in the spectra of these complexes in CH2Cl2 or cyclohexane solutions Quant. correlation was established between energy of the ligand field transitions and energy of the inverse charge-transfer transitions.

There is still a lot of research devoted to this compound(SMILES：[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2)Synthetic Route of C10H10Cl2N2Pt, and with the development of science, more effects of this compound(15227-42-6) can be discovered.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Multiresponse Shape-Memory Nanocomposite with a Reversible Cycle for Powerful Artificial Muscles, published in 2021-02-09, which mentions a compound: 693-67-4, Name is 1-Bromoundecane, Molecular C11H23Br, Name: 1-Bromoundecane.

In the field of bionic soft robots and microrobots, artificial muscle materials have exhibited unique potential for cutting-edge applications. However, current mainstream thermal-responsive artificial muscles based on semicrystalline polymers (SCPs), despite their excellent phys. properties, suffer from the limitation of environmental stimuli in practice, while their photodriven counterparts adopting liquid crystal elastomers (LCEs) lack ductility. Herein, a novel multifunctional programmable artificial muscle with a unique patch-sewing structure formed by π-π stacking between azobenzene groups was designed, which combined the advantages of SCPs and LCEs. The nanocomposite demonstrated a unique combination between artificial muscle performance (46.5 times the energy d. and 26.6 times the power d. of human skeletal muscles) and programmability (274.84% strain and 100% shape-memory recovery rate within 1 s). Meanwhile, coupling the photoisomerization of azobenzene and the photothermal conversion of gold nanorods, the cycle of deformation triggered by UV light and restoring by IR light could be accomplished rapidly within 30 s. A COMSOL Multiphysics model was established and the corresponding finite element anal. verified the photoactuation and captured the general principle of light initiation in elastomers. These demonstrate that the multifunctional programmable elastomer is promising for artificial muscle applications, especially for photoinduced actuation.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Yan, Xinlong; Dong, Qing; Li, Ying; Meng, Lizhen; Hao, Zhiqiang; Han, Zhangang; Lu, Guo-Liang; Lin, Jin published the article 《Aerobic oxidation of primary benzylic amines to amides and nitriles catalyzed by ruthenium carbonyl clusters carrying N,O-bidentate ligands》. Keywords: trinuclear ruthenium carbonyl catalyst preparation; nitrile preparation; amide preparation; benzylic amine aerobic oxidation.They researched the compound: Picolinamide( cas:1452-77-3 ).Name: Picolinamide. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1452-77-3) here.

Four trinuclear ruthenium carbonyl clusters were synthesized from the reactions of Ru3(CO)12 with the corresponding N,O-bidentate ligands (two pyridyl alcs. and two Schiff bases) resp. in a ratio of 1 : 2. Three new complexes were fully characterized by elemental anal., FT-IR, NMR and X-ray crystallog. The catalytic activity of these ruthenium complexes for the aerobic oxidation of primary benzylic amines to amides and nitriles in the presence of t-BuOK was investigated.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem